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Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer.
Jamaluddin, M Fairuz B; Ko, Yi-An; Ghosh, Arnab; Syed, Shafiq M; Ius, Yvette; O'Sullivan, Rachel; Netherton, Jacob K; Baker, Mark A; Nahar, Pravin; Jaaback, Kenneth; Tanwar, Pradeep S.
Afiliación
  • Jamaluddin MFB; Global Centre for Gynecological Diseases, University of Newcastle, LS236, University Drive, Callaghan, NSW 2308, Australia; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institut
  • Ko YA; Global Centre for Gynecological Diseases, University of Newcastle, LS236, University Drive, Callaghan, NSW 2308, Australia; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institut
  • Ghosh A; Global Centre for Gynecological Diseases, University of Newcastle, LS236, University Drive, Callaghan, NSW 2308, Australia; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institut
  • Syed SM; Global Centre for Gynecological Diseases, University of Newcastle, LS236, University Drive, Callaghan, NSW 2308, Australia; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institut
  • Ius Y; Hunter New England Centre for Gynecological Cancer, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
  • O'Sullivan R; Hunter New England Centre for Gynecological Cancer, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
  • Netherton JK; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  • Baker MA; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  • Nahar P; Department of Maternity and Gynecology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
  • Jaaback K; Hunter New England Centre for Gynecological Cancer, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
  • Tanwar PS; Global Centre for Gynecological Diseases, University of Newcastle, LS236, University Drive, Callaghan, NSW 2308, Australia; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institut
Cell Rep Med ; 3(9): 100738, 2022 09 20.
Article en En | MEDLINE | ID: mdl-36103879
Endometrial cancer is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over the last two decades. Despite the understanding of the major signaling pathways driving the growth and metastasis of endometrial cancer, clinical trials targeting these signals have reported poor outcomes. The heterogeneous nature of endometrial cancer is suspected to be one of the key reasons for the failure of targeted therapies. In this study, we perform a sequential window acquisition of all theoretical fragment ion spectra (SWATH)-based comparative proteomic analysis of 63 tumor biopsies collected from 20 patients and define differences in protein signature in multiple regions of the same tumor. We develop organoids from multiple biopsies collected from the same tumor and show that organoids capture heterogeneity in endometrial cancer growth. Overall, using quantitative proteomics and patient-derived organoids, we define the heterogeneous nature of endometrial cancer within a patient's tumor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Proteómica Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cell Rep Med Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Proteómica Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cell Rep Med Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos