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Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis.
Pankey, Brianna S; Riedel, Michael C; Cowan, Isis; Bartley, Jessica E; Pintos Lobo, Rosario; Hill-Bowen, Lauren D; Salo, Taylor; Musser, Erica D; Sutherland, Matthew T; Laird, Angela R.
Afiliación
  • Pankey BS; Department of Psychology, Florida International University, Miami, FL, USA. bpank001@fiu.edu.
  • Riedel MC; Department of Physics, Florida International University, Miami, FL, USA.
  • Cowan I; Department of Psychology, Old Dominion University, Norfolk, VA, USA.
  • Bartley JE; Department of Physics, Florida International University, Miami, FL, USA.
  • Pintos Lobo R; Department of Psychology, Florida International University, Miami, FL, USA.
  • Hill-Bowen LD; Department of Psychology, Florida International University, Miami, FL, USA.
  • Salo T; Department of Psychology, Florida International University, Miami, FL, USA.
  • Musser ED; Department of Psychology, Florida International University, Miami, FL, USA.
  • Sutherland MT; Department of Psychology, Florida International University, Miami, FL, USA.
  • Laird AR; Department of Physics, Florida International University, Miami, FL, USA.
Behav Brain Funct ; 18(1): 9, 2022 Sep 13.
Article en En | MEDLINE | ID: mdl-36100907
BACKGROUND: Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore, how structural alterations may be associated with brain function, as measured by task-free and task-based functional connectivity, remains to be elucidated. METHODS: Using emergent meta-analytic techniques, we sought to first identify a consensus of structural alterations in PTSD using the anatomical likelihood estimation (ALE) approach. Next, we generated functional profiles of identified convergent structural regions utilizing resting-state functional connectivity (rsFC) and meta-analytic co-activation modeling (MACM) methods. Finally, we performed functional decoding to examine mental functions associated with our ALE, rsFC, and MACM brain characterizations. RESULTS: We observed convergent structural alterations in a single region located in the medial prefrontal cortex. The resultant rsFC and MACM maps identified functional connectivity across a widespread, whole-brain network that included frontoparietal and limbic regions. Functional decoding revealed overlapping associations with attention, memory, and emotion processes. CONCLUSIONS: Consensus-based functional connectivity was observed in regions of the default mode, salience, and central executive networks, which play a role in the tripartite model of psychopathology. Taken together, these findings have important implications for understanding the neurobiological mechanisms associated with PTSD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Behav Brain Funct Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Behav Brain Funct Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido