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Focusing the pivotal role of nanotechnology in Huntington's disease: an insight into the recent advancements.
Singh, Sukhbir; Sharma, Neelam; Sachdeva, Monika; Behl, Tapan; Zahoor, Ishrat; Fuloria, Neeraj Kumar; Sekar, Mahendran; Fuloria, Shivkanya; Subramaniyan, Vetriselvan; Alsubayiel, Amal M; Dailah, Hamed Ghaleb; Naved, Tanveer; Bhatia, Saurabh; Al-Harrasi, Ahmed; Aleya, Lotfi.
Afiliación
  • Singh S; Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
  • Hema; Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
  • Sharma N; Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India. neelam.mdu@gmail.com.
  • Sachdeva M; Fatimah College of Health Sciences, Al Ain, United Arab Emirates.
  • Behl T; School of Health Sciences, University of Petroleum and Energy Studies, Bidholi, 248007, Dehradun, Uttarakhand, India. tapanbehl31@gmail.com.
  • Zahoor I; Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
  • Fuloria NK; Faculty of Pharmacy and Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong, Kedah, Malaysia.
  • Sekar M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia.
  • Fuloria S; Faculty of Pharmacy and Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong, Kedah, Malaysia.
  • Subramaniyan V; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor, Malaysia.
  • Alsubayiel AM; Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia.
  • Dailah HG; Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia.
  • Naved T; Amity Institute of Pharmacy, Amity University, Noida, India.
  • Bhatia S; School of Health Sciences, University of Petroleum and Energy Studies, Bidholi, 248007, Dehradun, Uttarakhand, India.
  • Al-Harrasi A; Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.
  • Aleya L; Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.
Environ Sci Pollut Res Int ; 29(49): 73809-73827, 2022 Oct.
Article en En | MEDLINE | ID: mdl-36100788
Neurodegeneration is the loss of neuronal capacity and structure over time which causes neurodegenerative disorders like Alzheimer, amyotrophic lateral sclerosis, Parkinson, and Huntington's disease (HD). This review is primarily concerned with HD, which was fully described by George Huntington in 1872. In developed countries, HD has become another common single-gene neurological disorder. Because of its autosomal dominant inheritance, the sickness affects both individuals and their families. Huntington disease has been recognized as a disorder that affects the complete body and brain in which the mutant huntingtin polyglutamine (polyQ) sequence is extensively increased and gets correlated to CAG trinucleotide which codes for glutamine (Q). These proteins have characteristics that produce apoptosis and dysfunction. HD is a lethal condition which needs an immediate diagnosis and treatment, and therefore, nanoparticle has come into sight out as opportunistic strategies for treatment of HD. Nanostructures have great potential to cross the blood brain barrier and also prevent breakdown of active molecule and reduces the drug toxicity. This review explains the distinguishing symptoms, genetics, and stages during the development of Huntington's disease, and also provides an overview of HD with an emphasis on its epidemiology, pathogenesis, and management. This review focuses on the latest studies on nanotechnology-related technologies, i.e., magnetic nanoparticle, solid lipid nanoparticle, and polymeric nanoparticle for Huntington's disease treatment. The pioneering patents and in-progress clinical trials related to Huntington's disease has also been summarized in this review.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Huntington Límite: Humans Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Huntington Límite: Humans Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania