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Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study.
Gillespie, Conor S; Bligh, Emily R; Poon, Michael T C; Solomou, Georgios; Islim, Abdurrahman I; Mustafa, Mohammad A; Rominiyi, Ola; Williams, Sophie T; Kalra, Neeraj; Mathew, Ryan K; Booth, Thomas C; Thompson, Gerard; Brennan, Paul M; Jenkinson, Michael D.
Afiliación
  • Gillespie CS; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK hlcgill2@liv.ac.uk.
  • Bligh ER; The Walton Centre NHS Foundation Trust, Liverpool, UK.
  • Poon MTC; Department of Neurosurgery, Institute of Neurological Sciences, Glasgow, UK.
  • Solomou G; Usher Institute, The University of Edinburgh, Edinburgh, UK.
  • Islim AI; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Mustafa MA; School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Rominiyi O; Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Manchester, UK.
  • Williams ST; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Kalra N; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Mathew RK; The Walton Centre NHS Foundation Trust, Liverpool, UK.
  • Booth TC; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Thompson G; Department of Neuroscience, The University of Sheffield, Sheffield, UK.
  • Brennan PM; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Jenkinson MD; Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
BMJ Open ; 12(9): e063043, 2022 09 13.
Article en En | MEDLINE | ID: mdl-36100297
INTRODUCTION: Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12-15 months (range 6-17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use of postoperative imaging to detect progression is of high importance to clinicians and patients, but currently, the optimal follow-up schedule is yet to be defined. It is also unclear how adhering to National Institute for Health and Care Excellence (NICE) guidelines-which are based on general consensus rather than evidence-affects patient outcomes such as progression-free and overall survival. The primary aim of this study is to assess MRI monitoring practice after surgery for glioblastoma, and to evaluate its association with patient outcomes. METHODS AND ANALYSIS: ImagiNg Timing aftER surgery for glioblastoma: an eVALuation of practice in Great Britain and Ireland is a retrospective multicentre study that will include 450 patients with an operated glioblastoma, treated with any adjuvant therapy regimen in the UK and Ireland. Adult patients ≥18 years diagnosed with glioblastoma and undergoing surgery between 1 August 2018 and 1 February 2019 will be included. Clinical and radiological scanning data will be collected until the date of death or date of last known follow-up. Anonymised data will be uploaded to an online Castor database. Adherence to NICE guidelines and the effect of being concordant with NICE guidelines will be identified using descriptive statistics and Kaplan-Meier survival analysis. ETHICS AND DISSEMINATION: Each participating centre is required to gain local institutional approval for data collection and sharing. Formal ethical approval is not required since this is a service evaluation. Results of the study will be reported through peer-reviewed presentations and articles, and will be disseminated to participating centres, patients and the public.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Aspecto: Ethics Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Aspecto: Ethics Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido