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Integrating the microneedles with carboplatin to facilitate the therapeutic effect of radiotherapy for skin cancers.
Chen, Min-Hua; Lee, Chun-Hung; Liang, Hsiang-Kuang; Huang, Su-Chin; Li, Jui-Ping; Lin, Cheng-An J; Chen, Jen-Kun.
Afiliación
  • Chen MH; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan City 320314, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan; Center for Biomedical Engineering in Cancer, Chung Yuan Christian University, Ta
  • Lee CH; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan City 320314, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan.
  • Liang HK; Department of Biomedical Engineering, National Taiwan University, Taipei City 10617, Taiwan; Division of Radiation Oncology, National Taiwan University Hospital, Taipei City 100225, Taiwan; Department of Radiation Oncology, Cancer Center Branch, National Taiwan University Hospital, Taipei City 10022
  • Huang SC; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan.
  • Li JP; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan.
  • Lin CJ; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan City 320314, Taiwan; Center for Biomedical Engineering in Cancer, Chung Yuan Christian University, Taoyuan City 320314, Taiwan.
  • Chen JK; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung City 40227, Taiwan; Graduated Institute of Life Sciences, National Defense Medical Center, Taipei City 11490, Taiwan
Biomater Adv ; 141: 213113, 2022 Oct.
Article en En | MEDLINE | ID: mdl-36099811
In most skin cancer patients, excisional surgery is required to remove tumorous tissue. However, the risk of locoregional recurrence after surgery alone is relatively high, particularly for a locally advanced stage of melanoma. Therefore, additional adjuvant treatments, such as radiotherapy, can be used after surgery to inhibit recurrent melanoma after surgical removal. To enhance local radiotherapy, we present the combined X-ray radiation and radiosensitizers (carboplatin) through microneedles (MNs) to treat melanoma. The MNs could be beneficial to precisely delivering carboplatin into the sub-epidermal layer of the melanoma region and alleviate patients' fear and discomfort during the drug administration compared to the traditional local injection. The carboplatin was loaded into the tips of dissolving gelatin MNs (carboplatin-MNs) through the molding method. The results show gelatin MNs have sufficient mechanical strength and can successfully administer carboplatin into the skin. Both in vitro and in vivo studies suggest that carboplatin can enhance radiotherapy in melanoma treatment. With a combination of radiotherapy and carboplatin, the inhibition effect of carboplatin delivered into the B16F10 murine melanoma model through MNs administration (1.2 mg/kg) is equivalent to that through an intravenous route (5 mg/kg). The results demonstrate a promise of combined carboplatin and X-ray radiation treatment in treating melanoma by MNs administration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos