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Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies-Singletons Cohort.
Tsoi, Kit Ying; Zhu, Yeyi; Wu, Jing; Sun, Qi; Hinkle, Stefanie N; Li, Ling-Jun; Chen, Zhen; Weir, Natalie L; Tsai, Michael Y; Ma, Ronald C W; Zhang, Cuilin.
Afiliación
  • Tsoi KY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • Zhu Y; Division of Research, Kaiser Permanente Northern California, Oakland, CA.
  • Wu J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
  • Sun Q; Glotech, Inc., Rockville, MD.
  • Hinkle SN; Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Li LJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Chen Z; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Weir NL; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Tsai MY; Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ma RCW; Global Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Zhang C; Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Diabetes ; 71(12): 2707-2715, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36095049
Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009-2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10-14, 15-26, 23-31, and 33-39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15-26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15-26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10-14 and 15-26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Diabetes Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Diabetes Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos