Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens.

Gnanasekar, Sathishkumar; Kasi, Gopinath; He, Xiaodong; Zhang, Kai; Xu, Liqun; Kang, En-Tang

Gnanasekar, Sathishkumar; Kasi, Gopinath; He, Xiaodong; Zhang, Kai; Xu, Liqun; Kang, En-Tang.

Afiliación

Gnanasekar S; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Kasi G; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
He X; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Zhang K; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Xu L; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.
Kang ET; Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, PR China.

Bioact Mater ; 21: 157-174, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36093325

RESUMEN

Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O2) for coping with bacterial infections. Although the existing porphyrin and non-porphyrin PSs were effective in APDT, the poor solubility, limited efficacy against Gram-negative bacteria, and non-specific distribution hinder their clinical applications. Accordingly, to promote the efficiency of conventional PSs, various polymer-driven modification and functionalization strategies have been adopted to engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements and state-of-the-art research in polymer-PSs hybrid materials developed for APDT applications. Further, the key research findings of the following aspects are considered in-depth with constructive discussions: i) PSs-integrated/functionalized polymeric composites through various molecular interactions; ii) PSs-deposited coatings on different substrates and devices to eliminate healthcare-associated infections; and iii) PSs-embedded films, scaffolds, and hydrogels for regenerative medicine applications.

Palabras clave

1O2, Singlet oxygen; APDT, Antibacterial photodynamic therapy; APTT, Antibacterial photothermal therapy; Antibacterial photodynamic therapy; BODIPY, Boron dipyrromethene; BP, Black phosphorus; Biomaterials; CS, Chitosan; CUR, Curcumin; CV, Crystal violet; Ce6, Chlorin e6; Conjugation; HYP, Hypocrellin; Hp, Hematoporphyrin; Hydrogels; ICG, Indocyanine green; MB, Methylene blue; MRSA, Methicillin-resistant Staphylococcus aureus; PCL, Poly(Îµ-caprolactone); PDA, Polydopamine; PDI, Photodynamic inactivation; PEG, Poly(ethylene glycol); PEI, Polyethylamine; PPIX, Protoporphyrin IX; PSs, Photosensitizers; PVA, Poly(vinyl alcohol); Photosensitizers; Polymers; RB, Rose bengal; ROS, Reactive oxygen species; α-CD, α-cyclodextrin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Bioact Mater Año: 2023 Tipo del documento: Article Pais de publicación: China

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