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Comprehensive characterization of pharmacogenes in a Taiwanese Han population.
Lu, Hsing-Fang; Liu, Ting-Yuan; Chou, Yu-Pao; Chang, Shih-Sheng; Hsieh, Yow-Wen; Chang, Jan-Gowth; Tsai, Fuu-Jen.
Afiliación
  • Lu HF; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
  • Liu TY; Center for Precision Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Chou YP; Center for Precision Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Chang SS; Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Hsieh YW; Division of Cardiovascular Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Chang JG; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
  • Tsai FJ; Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
Front Genet ; 13: 948616, 2022.
Article en En | MEDLINE | ID: mdl-36092904
Pharmacogenetic (PGx) testing has not been well adopted in current clinical practice. The phenotypic distribution of clinically relevant pharmacogenes remains to be fully characterized in large population cohorts. In addition, no study has explored actionable PGx alleles in the East Asian population at a large scale. This study comprehensively analyzed 14 actionable pharmacogene diplotypes and phenotypes in 172,854 Taiwanese Han individuals by using their genotype data. Furthermore, we analyzed data from electronic medical records to investigate the effect of the actionable phenotypes on the individuals. The PGx phenotype frequencies were comparable between our cohort and the East Asian population. Overall, 99.9% of the individuals harbored at least one actionable PGx phenotype, and 29% of them have been prescribed a drug to which they may exhibit an atypical response. Our findings can facilitate the clinical application of PGx testing and the optimization of treatment and dosage individually.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza