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Life-threatening hemophagocytic syndrome triggered by disseminated toxoplasmosis in a young patient with previously unknown AIDS.
Guiraud, V; Verney, C; Tetelboum, N; Argy, N; Debus, J; Herbel, S; Thy, M; Ricard, J D; Roux, D; Zucman, N.
Afiliación
  • Guiraud V; Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France.
  • Verney C; Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France.
  • Tetelboum N; Université de Paris, AP-HP, hôpital Louis Mourier, DMU DREAM, department of radiology, 92700 Colombes, France.
  • Argy N; Université de Paris, AP-HP, Hôpital Bichat-Claude Bernard, DMU BIOGEM, Laboratoire de Parasitologie-Mycologie, 75018 Paris, France; Université de Paris, UMR 261 MERIT, IRD, faculté de pharmacie, 75006 Paris, France.
  • Debus J; Université de Paris, AP-HP, hôpital Louis Mourier, DMU BIOGEM, hématologie biologique et transfusion, 92700 Colombes, France.
  • Herbel S; Université de Paris, AP-HP, hôpital Bichat-Claude Bernard, DMU INVICTUS, service de maladies infectieuses et tropicales, 75018 Paris, France.
  • Thy M; Université de Paris, AP-HP, hôpital Bichat-Claude Bernard, DMU INVICTUS, service de maladies infectieuses et tropicales, 75018 Paris, France.
  • Ricard JD; Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France; Université de Paris, UMR 1137 IAME, Inserm, 75018 Paris, France.
  • Roux D; Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France; Université de Paris, institut Necker-Enfants Malades, Inserm U1151, CNRS UMR 8253, 75015 Paris, France.
  • Zucman N; Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France. Electronic address: noemie.zucman@gmail.com.
Rev Med Interne ; 43(10): 622-625, 2022 Oct.
Article en En | MEDLINE | ID: mdl-36089427
Hemophagocytic syndrome is a rare life-threatening disorder that can be triggered by various conditions such as HIV infection and opportunistic agents. We report a case of disseminated toxoplasmosis complicated with severe hemophagocytic syndrome and revealing an unknown acquired immunodeficiency syndrome. The patient presented with multiple organ failure in intensive care unit. Once diagnosed, he benefitted from etoposide infusion, administration of specific anti-toxoplasmosis treatments and secondary antiretroviral therapy. He was alive at intensive care unit discharge and returned home with little sequalae. This case illustrates both the importance of rapid investigations of hemophagocytic syndrome etiologies in HIV positive patients and the necessity to prompt etoposide and specific treatments in order to improve potentially dramatic outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Toxoplasmosis / Síndrome de Inmunodeficiencia Adquirida / Linfohistiocitosis Hemofagocítica Tipo de estudio: Diagnostic_studies Límite: Humans / Male Idioma: En Revista: Rev Med Interne Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Toxoplasmosis / Síndrome de Inmunodeficiencia Adquirida / Linfohistiocitosis Hemofagocítica Tipo de estudio: Diagnostic_studies Límite: Humans / Male Idioma: En Revista: Rev Med Interne Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia