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Racial/ethnic differences in fibrosis prevalence and progression in biopsy-proven steatosis: A focus on the Asian American population.
Kim, Rebecca G; Chu, Janet N; Vittinghoff, Eric; Deng, Jasmine; Reaso, Jewel N; Grenert, James P; Khalili, Mandana.
Afiliación
  • Kim RG; Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Chu JN; Division of Gastroenterology and Hepatology, Zuckerberg San Francisco General, San Francisco, California, USA.
  • Vittinghoff E; Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Deng J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Reaso JN; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
  • Grenert JP; Division of Gastroenterology and Hepatology, Zuckerberg San Francisco General, San Francisco, California, USA.
  • Khalili M; Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
Hepatol Commun ; 6(11): 3024-3035, 2022 11.
Article en En | MEDLINE | ID: mdl-36087033
Fatty liver disease (FLD) is a leading cause of chronic liver disease (CLD) globally, and vulnerable populations are disproportionately affected. Prior studies have suggested racial/ethnic differences in FLD prevalence and severity; however, these studies often excluded Asian Americans. This study aims to evaluate racial/ethnic differences in the prevalence of, and predictors associated with steatohepatitis, advanced fibrosis, and fibrosis progression over time within a diverse population. Using descriptive analyses and multivariable modeling, we performed a longitudinal evaluation of 648 patients with histologic evidence of FLD (steatosis or steatohepatitis) from August 2009 to February 2020 within San Francisco's safety-net health care system. Overall demographics were median age of 53 years, 54% male, and 38% Asian (40% Hispanic, 14% White). On histology, 61% had steatohepatitis and 30% had advanced fibrosis (≥F3). The comparison between steatosis and steatohepatitis groups showed differences in sex, race/ethnicity, metabolic risk factors, and co-existing CLD (predominantly viral hepatitis); patients with steatosis were more likely to be Asian (50%), and those with steatohepatitis were more likely to be Hispanic (51%). On multivariable modeling, while Asian race (vs. non-Asian) was not associated with steatohepatitis or advanced fibrosis when models included all relevant clinical predictors, Asian race was associated with higher relative risk of fibrosis progression as defined by change in Fibrosis-4 category over time (relative risk ratio = 1.9; p = 0.047). Conclusion: In this vulnerable population with a large proportion of Asian Americans, Asian race was associated with progression of fibrosis. Given the relative paucity of data in this high-risk group, future studies should confirm these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis / Asiático / Disparidades en el Estado de Salud / Hígado Graso Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality / Patient_preference Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Hepatol Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis / Asiático / Disparidades en el Estado de Salud / Hígado Graso Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality / Patient_preference Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Hepatol Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos