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The Pioneer Advantage: Filling the blank spots on the map of genome diversity in Europe.
Oleksyk, Taras K; Wolfsberger, Walter W; Schubelka, Khrystyna; Mangul, Serghei; O'Brien, Stephen J.
Afiliación
  • Oleksyk TK; Uzhhorod National University, Uzhhorod, 88000, Ukraine.
  • Wolfsberger WW; Oakland University, Department of Biological Sciences, Rochester, 48309 MI 48309-4479, USA.
  • Schubelka K; Oakland University, Department of Biological Sciences, Rochester, 48309 MI 48309-4479, USA.
  • Mangul S; Oakland University, Department of Biological Sciences, Rochester, 48309 MI 48309-4479, USA.
  • O'Brien SJ; University of Southern California, USC School of Pharmacy, Los Angeles, CA 90089, USA.
Gigascience ; 112022 09 09.
Article en En | MEDLINE | ID: mdl-36085557
Documenting genome diversity is important for the local biomedical communities and instrumental in developing precision and personalized medicine. Currently, tens of thousands of whole-genome sequences from Europe are publicly available, but most of these represent populations of developed countries of Europe. The uneven distribution of the available data is further impaired by the lack of data sharing. Recent whole-genome studies in Eastern Europe, one in Ukraine and one in Russia, demonstrated that local genome diversity and population structure from Eastern Europe historically had not been fully represented. An unexpected wealth of genomic variation uncovered in these studies was not so much a consequence of high variation within their population, but rather due to the "pioneer advantage." We discovered more variants because we were the first to prospect in the Eastern European genome pool. This simple comparison underscores the importance of removing the remaining geographic genome deserts from the rest of the world map of the human genome diversity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Genómica Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Gigascience Año: 2022 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Genómica Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Gigascience Año: 2022 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Estados Unidos