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Radiological and pathological assessment with EOB-MRI after Y90 radiation lobectomy prior to liver resection for hepatocellular carcinoma.
Bekki, Yuki; Mahamid, Ahmad; Lewis, Sara; Ward, Stephen C; Simpson, William; Argiriadi, Pamela; Kamath, Amita; Facciuto, Lucas; Patel, Rahul S; Kim, Edward; Schiano, Thomas D; Facciuto, Marcelo E.
Afiliación
  • Bekki Y; Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Mahamid A; Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Lewis S; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Ward SC; The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, NY, 10029, USA.
  • Simpson W; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Argiriadi P; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Kamath A; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Facciuto L; Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Patel RS; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Kim E; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Schiano TD; Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Facciuto ME; Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: marcelo.facciuto@mountsinai.org.
HPB (Oxford) ; 24(12): 2185-2192, 2022 12.
Article en En | MEDLINE | ID: mdl-36085263
BACKGROUND: Radiation lobectomy (RL) utilizes Yttrium-90 (Y90) radioembolization for achieving tumor control and inducing contralateral lobe hypertrophy. Our objective was to evaluate the chronological changes occurring radiologically and histopathologically after Y90 RL. METHODS: We retrospectively reviewed 22 patients with chronic liver disease who underwent Y90 RL prior to planned liver resection for hepatocellular carcinoma. Gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (EOB-MRI) was performed every 3 months. RESULTS: Future liver remnant volume (FLRV) significantly increased up to 9 months after Y90 RL. Gd-EOB-DTPA uptake in the treated lobe experienced a 40% reduction in enhancement ratio (ER) during ensuing first 3 months, and never recovered. The reduced ER in the non-tumoral parenchyma was significantly correlated with increased FLRV and FLR (r = 0.41 and r = 0.35, respectively; both p < 0.01). Histopathological evaluation of non-tumor liver tissue found features of sinusoidal obstruction syndrome as an early change after Y90 RL (median 5.7 months) and parenchymal collapse as a late change (mean 11 months). DISCUSSION: The reduced uptake of Gd-EOB-DTPA at 3 months post Y90 RL correlates with a significant increase in FLRV prior to liver resection. EOB-MRI evaluation at 3 months can guide future plan of action after Y90 RL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Qualitative_research Límite: Humans Idioma: En Revista: HPB (Oxford) Asunto de la revista: GASTROENTEROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Qualitative_research Límite: Humans Idioma: En Revista: HPB (Oxford) Asunto de la revista: GASTROENTEROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido