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Chiral sulfonamides with various N-heterocyclic and aromatic units - Synthesis and antiviral activity evaluation.
Iwan, Dominika; Kaminska, Karolina; Denel-Bobrowska, Marta; Olejniczak, Agnieszka B; Wojaczynska, Elzbieta.
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  • Iwan D; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland.
  • Kaminska K; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland.
  • Denel-Bobrowska M; Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Lódz, Poland.
  • Olejniczak AB; Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Lódz, Poland.
  • Wojaczynska E; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland. Electronic address: elzbieta.wojaczynska@pwr.edu.pl.
Biomed Pharmacother ; 153: 113473, 2022 Sep.
Article en En | MEDLINE | ID: mdl-36076578
Chiral sulfonamides with aromatic fragments are important chemical building blocks found widely in many natural products, catalysts, and molecules of biological importance. In this report, we describe the efficient synthesis of a series of chiral sulfonamides which, in addition to the aromatic part (phenyl, biphenyl, and dansyl units), possess N-heterocyclic systems. The described compounds were obtained by nucleophilic substitution of chiral N-heterocyclic amines and commercially available aromatic sulfonyl chlorides under mild conditions. All derivatives were examined in antiviral assay against AdV5, HSV-1, HPIV-3, HCMV, and EMCV viruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Herpesvirus Humano 1 Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Francia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Herpesvirus Humano 1 Idioma: En Revista: Biomed Pharmacother Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Francia