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Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster.
Feitzinger, Anna A; Le, Anthony; Thompson, Ammon; Haseeb, Mehnoor; Murugesan, Mohan Koumar; Tang, Austin M; Lott, Susan E.
Afiliación
  • Feitzinger AA; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA. afeitzinger@ucdavis.edu.
  • Le A; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
  • Thompson A; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
  • Haseeb M; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
  • Murugesan MK; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
  • Tang AM; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
  • Lott SE; Department of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
BMC Genomics ; 23(1): 641, 2022 Sep 08.
Article en En | MEDLINE | ID: mdl-36076188
BACKGROUND: Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. RESULTS: Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. CONCLUSIONS: Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Drosophila melanogaster Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Drosophila melanogaster Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido