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Cannabidiol-loaded injectable chitosan-based hydrogels promote spinal cord injury repair by enhancing mitochondrial biogenesis.
Zhang, Hongyan; Hu, Tian; Xiong, Mingxin; Li, Shanshan; Li, Wei-Xiong; Liu, Jinwen; Zhou, Xiang; Qi, Jian; Jiang, Gang-Biao.
Afiliación
  • Zhang H; College of Veterinary, South China Agricultural University, Guangzhou 510642, China; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China. Electronic address: qiyue1031@outlook.com.
  • Hu T; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China.
  • Xiong M; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China.
  • Li S; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China.
  • Li WX; College of Veterinary, South China Agricultural University, Guangzhou 510642, China; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China.
  • Liu J; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China.
  • Zhou X; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
  • Qi J; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
  • Jiang GB; College of Veterinary, South China Agricultural University, Guangzhou 510642, China; College of Materials and energy, South China Agricultural University, Guangzhou 510642, China. Electronic address: jgb3h@163.com.
Int J Biol Macromol ; 221: 1259-1270, 2022 Nov 30.
Article en En | MEDLINE | ID: mdl-36075309
The treatment of traumatic spinal cord injury (SCI) remains challenging as the neuron regeneration is impaired by irregular cavity and apoptosis. An injectable in situ gelling hydrogel is therefore developed for the local delivery of cannabidiol (CBD) through a novel method based on polyelectrolyte (PEC) interaction of sodium carboxymethylcellulose (CMC) and chitosan (CS). It can be injected into the spinal cord cavity with a 26-gauge syringe before gelation, and gelled after 110 ± 10 s. Of note, the in-situ forming hydrogel has mechanical properties similar to spinal cord. Moreover, the CBD-loaded hydrogels sustain delivery of CBD for up to 72 h, resulting in reducing apoptosis in SCI by enhancing mitochondrial biogenesis. Importantly, the CBD-loaded hydrogels raise neurogenesis more than pure hydrogels both in vivo and in vitro, further achieving significant recovery of motor and urinary function in SCI rats. Thus, it suggested that CMC/CS/CBD hydrogels could be used as promising biomaterials for tissue engineering and SCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Cannabidiol / Quitosano Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Cannabidiol / Quitosano Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos