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Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood.
Borcherding, Nicholas; Jia, Wentong; Giwa, Rocky; Field, Rachael L; Moley, John R; Kopecky, Benjamin J; Chan, Mandy M; Yang, Bin Q; Sabio, Jessica M; Walker, Emma C; Osorio, Omar; Bredemeyer, Andrea L; Pietka, Terri; Alexander-Brett, Jennifer; Morley, Sharon Celeste; Artyomov, Maxim N; Abumrad, Nada A; Schilling, Joel; Lavine, Kory; Crewe, Clair; Brestoff, Jonathan R.
Afiliación
  • Borcherding N; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: borcherding.n@wustl.edu.
  • Jia W; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Giwa R; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Field RL; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Moley JR; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Kopecky BJ; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Chan MM; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Yang BQ; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Sabio JM; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Walker EC; Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Osorio O; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Bredemeyer AL; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Pietka T; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Alexander-Brett J; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Morley SC; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Abumrad NA; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Schilling J; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Lavine K; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
  • Crewe C; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Brestoff JR; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: brestoff@wustl.edu.
Cell Metab ; 34(10): 1499-1513.e8, 2022 10 04.
Article en En | MEDLINE | ID: mdl-36070756
Adipocytes transfer mitochondria to macrophages in white and brown adipose tissues to maintain metabolic homeostasis. In obesity, adipocyte-to-macrophage mitochondria transfer is impaired, and instead, adipocytes release mitochondria into the blood to induce a protective antioxidant response in the heart. We found that adipocyte-to-macrophage mitochondria transfer in white adipose tissue is inhibited in murine obesity elicited by a lard-based high-fat diet, but not a hydrogenated-coconut-oil-based high-fat diet, aging, or a corn-starch diet. The long-chain fatty acids enriched in lard suppress mitochondria capture by macrophages, diverting adipocyte-derived mitochondria into the blood for delivery to other organs, such as the heart. The depletion of macrophages rapidly increased the number of adipocyte-derived mitochondria in the blood. These findings suggest that dietary lipids regulate mitochondria uptake by macrophages locally in white adipose tissue to determine whether adipocyte-derived mitochondria are released into systemic circulation to support the metabolic adaptation of distant organs in response to nutrient stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Blanco / Antioxidantes Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Blanco / Antioxidantes Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos