Synthesis and Characterization of Novel Schiff Bases Derived from 2-Butyl-4-chloro Imidazole for the Enhanced Antimicrobial Property.
Appl Biochem Biotechnol
; 195(1): 253-263, 2023 Jan.
Article
en En
| MEDLINE
| ID: mdl-36070167
In this study, a novel Schiff base was synthesized which comprises a core moiety of 2-butyl-4-chloro imidazole. The ligand was synthesized by the reaction between the carbonyl compound 4-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl) methyl] benzoate and primary hydrazine compounds such as 2,4-dinitrophenylhydrazine in the presence of an alcoholic solvent and an acid catalyst. The synthesized Schiff base ligand is characterized by mass and spectral analysis including NMR. The appearance of extended conjugation of the π-electrons system between active 2-butyl-4-chloro imidazole moieties with nitro substituted phenyl ring. The ligands are assessed for an antibacterial activity for Escherichia coli and Staphylococcus aureus to evaluate the inhibition potential by MIC and well diffusion method. The biological activity of the ligand has shown a significant property against the Gram-negative bacterium, E. coli, and Gram-positive bacterium, S. aureus of about 27 mm and 28 mm of inhibitory action, respectively. This study paves the way for the development of novel antimicrobial agents for emerging clinical pathogens.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bases de Schiff
/
Antiinfecciosos
Idioma:
En
Revista:
Appl Biochem Biotechnol
Año:
2023
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos