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Silkworm spinning inspired 3D printing toward a high strength scaffold for bone regeneration.
Yao, Yingkai; Guan, Diqin; Zhang, Chenke; Liu, Jing; Zhu, Xufeng; Huang, Tingting; Liu, Jie; Cui, Hongjuan; Tang, Kang-Lai; Lin, Jinxin; Li, Fengyu.
Afiliación
  • Yao Y; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
  • Guan D; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
  • Zhang C; Sports Medicine Center, Department of Orthopedic Surgery, Southwest Hospital, The Third Military Medical University, Gaotanyan Str. 30, Shapingba District, Chongqing 400038, China. tangkanglai@hotmail.com.
  • Liu J; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
  • Zhu X; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
  • Huang T; Key Laboratory of Optoelectronic Materials Chemistry and Physics, Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter, 155 Yangqiao Road West, Fuzhou 350002, China. tthuang@fjirsm.ac.cn.
  • Liu J; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
  • Cui H; Sate Key Laboratory of Silkworm Genome Biology, Southwest University of China, Chongqing, 400715, China.
  • Tang KL; Sports Medicine Center, Department of Orthopedic Surgery, Southwest Hospital, The Third Military Medical University, Gaotanyan Str. 30, Shapingba District, Chongqing 400038, China. tangkanglai@hotmail.com.
  • Lin J; Key Laboratory of Optoelectronic Materials Chemistry and Physics, Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter, 155 Yangqiao Road West, Fuzhou 350002, China. tthuang@fjirsm.ac.cn.
  • Li F; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe Di
J Mater Chem B ; 10(36): 6946-6957, 2022 09 21.
Article en En | MEDLINE | ID: mdl-36069158
Inspired by the silkworm spinning process for production of tough cocoons, a gradient printing-assembly technique with silk fibroin (SF) and hydroxyapatite (HA) to achieve high strength scaffolds for bone regeneration is developed. A coaxial extrude-nozzle is employed to provide gathered thickening and shearing for aligned assembly. The aligned SF-HA assembles into the compacted nanostructure, which performs a maximum compressive strength of 166 MPa and bending strength of 40 MPa. Scaffolds with various morphologies could be arbitrarily constructed via extruded 3D printing for the regeneration of cortical bone or cancellous bone. The hemolysis quantification of red blood cells (RBCs), proliferation and flow cytometry of bone marrow stem cells (BMSCs) have proved the excellent biocompatibility of the printed scaffolds. Osteogenic induced differentiation assay in vitro and surgical intervention for rat femoral defect repairing have verified the successful osteogenesis with high mechanical strength and remarkable stability in the physiological environment. The silkworm spinning inspired 3D printing offers a facile approach for the fabrication of implantable scaffolds with high strength and excellent biocompatibility, which is highly desired for the applications of bone tissue engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombyx / Fibroínas Límite: Animals Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombyx / Fibroínas Límite: Animals Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido