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Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.
Carugati, Manuela; Arif, Sana; Sudan, Debra Lynn; Collins, Bradley Henry; Haney, John Carroll; Schroder, Jacob Niall; Reynolds, John Michael; Lewis, Sarah Stamps; Yarrington, Michael Edwards; Miller, Rachel Ann; Alexander, Barbara Dudley.
Afiliación
  • Carugati M; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
  • Arif S; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
  • Sudan DL; Department of Surgery, Division of Abdominal Transplant Surgery, Duke University, Durham, North Carolina, USA.
  • Collins BH; Department of Surgery, Division of Abdominal Transplant Surgery, Duke University, Durham, North Carolina, USA.
  • Haney JC; Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University, Durham, North Carolina, USA.
  • Schroder JN; Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University, Durham, North Carolina, USA.
  • Reynolds JM; Department of Medicine, Transplant Pulmonology, Duke University, Durham, North Carolina, USA.
  • Lewis SS; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
  • Yarrington ME; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
  • Miller RA; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
  • Alexander BD; Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA.
Am J Transplant ; 22(12): 3021-3030, 2022 12.
Article en En | MEDLINE | ID: mdl-36056456
Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult SOT recipients at Duke University over a 5-year period (2015-2019). Among 2073 consecutive SOT recipients, 198 IP-SSI were identified. The IP-SSI rate declined over the period (14.4% in 2015 vs. 8.3% in 2019) and was higher among multi-organ compared with single-organ transplants (33.9% vs. 8.1%, p < .01). SOT recipients with IP-SSI had longer hospital stays than patients without SSI (30.0 vs. 17.0 days, p < .01). Transplant hospitalization (9.6% vs. 2.2%, p < .01), 6-month (11.6% vs. 3.3%, p < .01), and 1-year mortality (15.7% vs. 5.8%, p < .01) were higher in SOT recipients with IP-SSI than in those without. While Gram-positive bacteria were the most common pathogens, urogenital Mollicute and atypical Mycobacteria were identified as an unexpected cause of IP-SSI, particularly among lung transplant recipients. The median time to IP-SSI was 24.0 (IQR 13.8-48.3) days, although the time to IP-SSI varied based on organ transplanted and the causative pathogen. IP-SSI is an important and potentially modifiable complication of SOT, associated with prolonged hospitalizations and reduced survival, particularly in the lung transplant population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infección de la Herida Quirúrgica / Trasplante de Órganos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infección de la Herida Quirúrgica / Trasplante de Órganos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos