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Multigenerational DNA methylation responses to copper exposure in Daphnia: Potential targets for epigenetic biomarkers?
Jeremias, Guilherme; Veloso, Telma; Gonçalves, Fernando J M; Van Nieuwerburgh, Filip; Pereira, Joana Luísa; Asselman, Jana.
Afiliación
  • Jeremias G; Department of Biology & CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Portugal.
  • Veloso T; Department of Biology & CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Portugal; CICECO - Aveiro Institute of Materials & Department of Chemistry, University of Aveiro, Portugal.
  • Gonçalves FJM; Department of Biology & CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Portugal.
  • Van Nieuwerburgh F; Laboratory of Pharmaceutical Biotechnology, Ghent University, 9000, Ghent, Belgium.
  • Pereira JL; Department of Biology & CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Portugal. Electronic address: jpereira@ua.pt.
  • Asselman J; Blue Growth Research Lab, Ghent University, Bluebridge Building, Ostend Science Park 1, 8400, Ostend, Belgium.
Chemosphere ; 308(Pt 1): 136231, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36055596
Epigenetic mechanisms are moving to the forefront of environmental sciences, as environmentally induced epigenetic changes shape biological responses to chemical contamination. This work focused on Daphnia as a representative of potentially threatened freshwater biota, aiming to gain an insight into the involvement of epigenetic mechanisms in their response and eventual adaptation to metal contamination. Copper-induced DNA methylation changes, their potential transgenerational inheritance, and life-history traits were assessed. Organisms with different histories of past exposure to copper were exposed to toxic levels of the element for one generation (F0) and then monitored for three subsequent unexposed generations (F1, F2, and F3). Overall, methylation changes targeted important genes for counteracting the effects of metals and oxidative stress, including dynein light chain, ribosomal kinase and nuclear fragile X mental retardation-interacting protein. Also, contrasting overall and gene-specific methylation responses were observed in organisms differing in their history of exposure to copper, with different transgenerational methylation responses being also identified among the two groups, without apparent life-history costs. Taken together, these results demonstrate the capacity of copper to promote epigenetic transgenerational inheritance in a manner related explicitly to history of exposure, thereby supporting the development and incorporation of epigenetic biomarkers in risk assessment frameworks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Daphnia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Chemosphere Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Daphnia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Chemosphere Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido