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Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function.
Garza, Luis A; Sheu, Mary; Kim, Noori; Tsai, Jerry; Alessi Cesar, Sabrina S; Lee, Jianming; Hawkins, Stacy S; Chien, Anna L; Kang, Sewon.
Afiliación
  • Garza LA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sheu M; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Kim N; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Tsai J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Alessi Cesar SS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Lee J; Unilever Human Biology Science and Technology, Trumbull, Connecticut, USA.
  • Hawkins SS; Unilever Human Biology Science and Technology, Trumbull, Connecticut, USA.
  • Chien AL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Kang S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: swk@jhmi.edu.
J Invest Dermatol ; 143(3): 374-385.e7, 2023 03.
Article en En | MEDLINE | ID: mdl-36055399
Laser resurfacing treatments for photoaged skin have improved dramatically over the past decades, but few studies have examined the molecular mechanisms underlying differences in clinical response. Seventeen white female participants with moderate-to-severe photoaging received nonablative fractional laser treatment on the face and forearm once monthly for 6 months. Biopsies for microarray analysis were performed at baseline and 7 days after facial treatment and at baseline and 1, 7, 14, and 29 days after forearm treatment in each participant, resulting in 119 total samples. Participants were stratified into fast (n = 11) and slow (n = 6) responders on the basis of the presence of clinical improvement after the first treatment. Microarray analysis revealed the upregulation of genes associated with matrix metalloproteinases, collagen and extracellular components, TGF-ß signaling, double-stranded RNA signaling, and retinoic acid synthesis after treatment that did not differ significantly between fast and slow responders. Cluster and enrichment analyses suggested significantly greater activation of lipid metabolism and keratinocyte differentiation in fast responders, who showed greater upregulation of acyltransferases, fatty acid elongases, fatty acid 2-hydroxylase, fatty acid desaturases, and specific keratins that may contribute to epidermal barrier function. These results create, to our knowledge, a previously unreported atlas of molecular changes that correlate with improvements in photoaging after laser therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Terapia por Láser Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Invest Dermatol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Terapia por Láser Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Invest Dermatol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos