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Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism.
Bjornsdottir, Sigridur; Ing, Steven; Mitchell, Deborah M; Sikjaer, Tanja; Underbjerg, Line; Hassan-Smith, Zaki; Sfeir, Jad; Gittoes, Neil J; Clarke L, Bart L.
Afiliación
  • Bjornsdottir S; Deparment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
  • Ing S; Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA.
  • Mitchell DM; Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Sikjaer T; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
  • Underbjerg L; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
  • Hassan-Smith Z; Centre for Endocrinology, Diabetes, and Metabolism, Queen Elizabeth Hospital, Birmingham, UK.
  • Sfeir J; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.
  • Gittoes NJ; Centre for Endocrinology, Diabetes, and Metabolism, Queen Elizabeth Hospital, Birmingham, UK.
  • Clarke L BL; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.
J Bone Miner Res ; 37(12): 2602-2614, 2022 12.
Article en En | MEDLINE | ID: mdl-36054571
Chronic hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone. This rare disorder is associated with a variety of complications. The prevalence, incidence, mortality, financial burden, and epidemiology of complications of this disorder are not well understood. This narrative review summarizes current information on the epidemiology and complications of chronic hypoparathyroidism. The reported prevalence of chronic hypoparathyroidism ranges from 6.4-37/100,000, and the incidence is reported to be 0.8-2.3/100,000/year. Mortality is not increased in studies from Denmark or South Korea but was increased in studies from Scotland and Sweden. The financial burden of this disorder is substantial because of increased health care resource utilization in two studies but not well quantitated. Recognized complications include hypercalciuria, nephrocalcinosis, kidney stones, and chronic kidney disease; low bone turnover and possibly upper extremity fractures; cardiac and vascular calcifications; basal ganglia calcifications, cataracts, infections, neuropsychiatric complications, and difficulties with pregnancy. This review concludes that chronic hypoparathyroidism is a rare disorder associated with significant morbidity that may not increase overall mortality but is associated with a substantial financial burden. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoparatiroidismo / Nefrocalcinosis Tipo de estudio: Health_economic_evaluation / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoparatiroidismo / Nefrocalcinosis Tipo de estudio: Health_economic_evaluation / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos