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Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction.
Watanabe, Kenichi; Hirayama, Masao; Arumugam, Somasundaram; Sugawara, Masayoshi; Kato, Hisanori; Nakamura, Sumiko; Ohtsubo, Ken'ichi; Matsumoto, Hitoshi; Nomi, Yuri; Homma, Noriyuki; Fujii, Yoshifumi; Murohashi, Naoto; A Thandavarayan, Rajarajan; Suzuki, Hiroshi; Fujihara, Kazuya; Kodama, Satoru; Sone, Hirohito.
Afiliación
  • Watanabe K; Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
  • Hirayama M; Niigata Bio-Research Park Co., Ltd., Japan.
  • Arumugam S; Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
  • Sugawara M; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, India.
  • Kato H; Department of Materials Engineering, National Institute of Technology, Nagaoka College, Japan.
  • Nakamura S; Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan.
  • Ohtsubo K; Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
  • Matsumoto H; Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
  • Nomi Y; Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
  • Homma N; Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.
  • Fujii Y; Cereal Food Section, Niigata Agricultural Research Institute Food Research Center, Japan.
  • Murohashi N; Niigata-Seifun Co., Ltd., Japan.
  • A Thandavarayan R; Bourbon Institutes of Health, Bourbon Corporation, Japan.
  • Suzuki H; Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
  • Fujihara K; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.
  • Kodama S; Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
  • Sone H; Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Heliyon ; 8(8): e10284, 2022 Aug.
Article en En | MEDLINE | ID: mdl-36051263
Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: Mean pre-intake baseline FMD values of HMT-BR-C, BR-C, and WR-C were 4.9%, 5.1%, and 4.9%, respectively, and those values 1 h post-intake were 6.3%, 5.1%, and 4.8%, respectively. There was no difference in intergroup comparisons of FMD using Dunnett's multiple comparison test. There was a significant increase in FMD only in HMT-BR-C in intragroup comparisons (P = 0.042 by paired-t test). In comparison with BR-C, no significant difference was noted in the postprandial glucose level nor in the content of total polyphenols and ferulic acid derivatives in HMT-BR-C. However, the 70% ethanol extracted from HMT-BR-C contained a significantly larger amount of free and bound ferulic acids than from BR-C. Conclusion: HMT-BR-C intake increased the postprandial FMD response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Heliyon Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Heliyon Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido