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Physical inactivity during adolescence heightens risk for cannabis use disorder in adulthood.
Tarter, Ralph E; Reynolds, Maureen; Vanyukov, Michael; Kirisci, Levent.
Afiliación
  • Tarter RE; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.
  • Reynolds M; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.
  • Vanyukov M; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.
  • Kirisci L; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.
Exp Clin Psychopharmacol ; 31(3): 704-714, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36048110
The association between physical inactivity and substance use throughout adolescence was prospectively investigated in relation to developing cannabis use disorder (CUD). Physical inactivity and substance use in males (N = 462) and females (N = 178) were measured at 12-14, 16, 19, and 22 years of age in a repeated measures design. A structured diagnostic interview was administered to formulate current CUD diagnosis at 22 years of age. Mixture modeling path analysis evaluated the association between physical inactivity, substance use, and CUD. Males: Slope of physical inactivity increase spanning 12-22 years of age mediates the association between number of parents with substance use disorder (SUD) and rate of increase in substance use frequency (prodrome) which mediates the association between physical inactivity (hypothesized vulnerability) and CUD. Females: Number of SUD parents predicts slope of physical inactivity increase in daughters throughout adolescence which covaries with slope of increasing substance use frequency culminating in CUD. The association between parental SUD load (number of SUD affected parents) and CUD was found to not be mediated by physical inactivity. Rate of increase in physical inactivity during adolescence in males and females is a facet of the vulnerability for CUD. These results have ramifications for prevention considering that numerous cognitive, behavior, and emotion features of CUD vulnerability are attenuated by exercise. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabis / Abuso de Marihuana / Trastornos Relacionados con Sustancias Tipo de estudio: Etiology_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Exp Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabis / Abuso de Marihuana / Trastornos Relacionados con Sustancias Tipo de estudio: Etiology_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Exp Clin Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos