Your browser doesn't support javascript.
loading
Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity: The EFIGRO Project.
Cadenas-Sanchez, Cristina; Idoate, Fernando; Cabeza, Rafael; Villanueva, Arantxa; Rodríguez-Vigil, Beatriz; Medrano, María; Osés, Maddi; Ortega, Francisco B; Ruiz, Jonatan R; Labayen, Idoia.
Afiliación
  • Cadenas-Sanchez C; Institute for Innovation & Sustainable Food Chain Development (ISFOOD), Department of Health Sciences, Public University of Navarre, Pamplona, Navarre, Spain.
  • Idoate F; Healthcare Research Institute of Navarre (IdiSNA), Pamplona, Spain.
  • Cabeza R; Promoting Fitness and Health Through Physical Activity (PROFITH) Research Group, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, Department of Physical and Sports Education, University of Granada, Granada, Spain.
  • Villanueva A; Radiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarre, Pamplona, Spain.
  • Rodríguez-Vigil B; Department of Electrical, Electronic and Communications Engineering, Public University of Navarre, Pamplona, Spain.
  • Medrano M; Healthcare Research Institute of Navarre (IdiSNA), Pamplona, Spain.
  • Osés M; Department of Electrical, Electronic and Communications Engineering, Public University of Navarre, Pamplona, Spain.
  • Ortega FB; Smart Cities Institute, Public University of Navarre, Pamplona, Spain.
  • Ruiz JR; Department of Magnetic Resonance Imaging, Osatek, University Hospital of Alava (HUA), Vitoria-Gasteiz, Spain.
  • Labayen I; Promoting Fitness and Health Through Physical Activity (PROFITH) Research Group, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, Department of Physical and Sports Education, University of Granada, Granada, Spain.
Diabetes Care ; 45(9): 1953-1960, 2022 09 01.
Article en En | MEDLINE | ID: mdl-36044664
OBJECTIVE: In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity. RESEARCH DESIGN AND METHODS: A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention. RESULTS: Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P < 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders -20% [P = 0.005] vs. nonresponders -1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss. CONCLUSIONS: The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrepeso / Hígado Graso Tipo de estudio: Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Diabetes Care Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrepeso / Hígado Graso Tipo de estudio: Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Diabetes Care Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos