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Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats.
Lin, Jing-Ying; Tsai, Bruce Chi-Kang; Kao, Hui-Chuan; Chiang, Chien-Yi; Chen, Yun-An; Chen, William Shao-Tsu; Ho, Tsung-Jung; Yao, Chun-Hsu; Kuo, Wei-Wen; Huang, Chih-Yang.
Afiliación
  • Lin JY; Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
  • Tsai BC; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Kao HC; Department of Public Health, Tzu Chi University, Hualien, Taiwan.
  • Chiang CY; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Chen YA; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
  • Chen WS; Department of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Ho TJ; School of Medicine, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Yao CH; Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Kuo WW; Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Huang CY; School of Post-Baccalaureate Chinese Medicine, College of Medicine, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Probiotics Antimicrob Proteins ; 15(5): 1287-1297, 2023 10.
Article en En | MEDLINE | ID: mdl-36044175
Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin (STZ)-induced diabetic rats. In this study, three different groups, namely control group, STZ-induced (55 mg/kg streptozotocin intraperitoneally) diabetic rats (DM), and DM rats treated with Lactobacillus reuteri GMNL-263 (1 × 109 CFU/rat/day), were utilized to study the protective effect of GMNL-263 in the hippocampus of STZ-induced diabetic rats. The results demonstrated that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing the cell survival pathways and repressing both inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes in the hippocampus in the DM group and decreased the level of inflammation and apoptosis in the hippocampus of DM rats. The IGF1R cell survival signaling pathway also improved after GMNL-263 treatment. These results indicate that probiotic GMNL-263 exerts beneficial effects in the brain of diabetic rats and has potential ability for clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Probióticos / Diabetes Mellitus Experimental / Limosilactobacillus reuteri Límite: Animals Idioma: En Revista: Probiotics Antimicrob Proteins Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Probióticos / Diabetes Mellitus Experimental / Limosilactobacillus reuteri Límite: Animals Idioma: En Revista: Probiotics Antimicrob Proteins Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos