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Current knowledge of protein palmitoylation in gliomas.
Tang, Feng; Liu, Zhenyuan; Chen, Xi; Yang, Jinzhou; Wang, Zefen; Li, Zhiqiang.
Afiliación
  • Tang F; Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
  • Liu Z; Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
  • Chen X; Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
  • Yang J; Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
  • Wang Z; Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, China. wangzf@whu.edu.cn.
  • Li Z; Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China. lizhiqiang@whu.edu.cn.
Mol Biol Rep ; 49(11): 10949-10959, 2022 Nov.
Article en En | MEDLINE | ID: mdl-36044113
Malignant tumor cells can obtain proliferative benefits from deviant metabolic networks. Emerging evidence suggests that lipid metabolism are dramatically altered in gliomas and excessive fatty acd accumulation is detrimentally correlated with the prognosis of glioma patients. Glioma cells possess remarkably high levels of free fatty acids, which, in turn, enhance post-translational modifications (e.g. palmitoylation). Our and other groups found that palmitoylational modification is essential for remaining intracellular homeostasis and cell survival. Disrupting the balance between palmitoylation and depalmitoylation affects glioma cell viability, apoptosis, invasion, self-renew and pyroptosis. In this review, we focused on summarizing roles and relevant mechanisms of protein palmitoylational modification in gliomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipoilación / Glioma Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipoilación / Glioma Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos