Your browser doesn't support javascript.
loading
Microvascular capillaroscopic abnormalities and occurrence of antinuclear autoantibodies in patients with sarcoidosis.
Cattelan, Francesco; Hysa, Elvis; Gotelli, Emanuele; Pizzorni, Carmen; Bica, Pietro Francesco; Grosso, Marco; Barisione, Emanuela; Paolino, Sabrina; Carmisciano, Luca; Sulli, Alberto; Smith, Vanessa; Cutolo, Maurizio.
Afiliación
  • Cattelan F; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Hysa E; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Gotelli E; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Pizzorni C; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Bica PF; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Grosso M; Pneumology Unit, IRCCS San Martino Polyclinic, Genoa, Italy.
  • Barisione E; Pneumology Unit, IRCCS San Martino Polyclinic, Genoa, Italy.
  • Paolino S; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Carmisciano L; Department of Health Sciences, University of Genova, Genoa, Italy.
  • Sulli A; Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCSS San Martino Polyclinic, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  • Smith V; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium.
  • Cutolo M; Department of Internal Medicine, Ghent University, Ghent, Belgium.
Rheumatol Int ; 42(12): 2199-2210, 2022 12.
Article en En | MEDLINE | ID: mdl-36040491
We described nailfold videocapillaroscopy (NVC) findings and estimated the prevalence of serum anti-nuclear (ANA) and extractable nuclear antigen autoantibodies (ENA) in a cohort of sarcoidosis patients, comparing them with adequate healthy controls (HCs) and with primary Raynaud's phenomenon patients (PRPs). NVC findings were also correlated with the occurrence of autoantibodies, current treatment, laboratory parameters, variables of lung function and whole-body imaging data. Twenty-six patients with sarcoidosis were assessed through NVC, laboratory parameters, pulmonary function tests, chest-X ray and 18- fluorodeoxyglucose positron emission tomography/computed tomography. The NVC parameters and ANA/ENA dosage were recorded also in 30 PRPs and 30 HCs. Sarcoidosis patients showed a higher rate of capillary dilations and nonspecific abnormalities and a lower mean capillary absolute number than PRPs and HCs (p < 0.01 for all comparisons). The prevalence of ANA positivity was higher in patients with sarcoidosis compared with PRPs and HCs (p < 0.02 for both), whereas ENA positivity was detected in one sarcoidosis patient (Ro52). Among sarcoidosis patients, the mean capillary absolute number negatively correlated with the C-reactive protein concentrations and was positively associated with the forced vital capacity percentage. Instead, a negative correlation was detected between serum ACE levels and the presence of capillary dilations (all p < 0.05). Our findings suggest a microvascular involvement in sarcoidosis whose investigation by NVC might be useful for the follow-up of patients displaying RP. Autoantibody positivity in sarcoidosis might suggest autoimmune implications in the disease or the production of autoantibodies reactive to tissue damage.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Raynaud / Sarcoidosis / Esclerodermia Sistémica Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheumatol Int Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Raynaud / Sarcoidosis / Esclerodermia Sistémica Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheumatol Int Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania