Your browser doesn't support javascript.
loading
Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability.
Majerova, Karolina; Zvarik, Milan; Ricon-Becker, Itay; Hanalis-Miller, Tsipi; Mikolaskova, Iveta; Bella, Vladimir; Mravec, Boris; Hunakova, Luba.
Afiliación
  • Majerova K; Institute of Immunology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
  • Zvarik M; Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
  • Ricon-Becker I; Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Computer Science, Comenius University, Bratislava, Slovakia.
  • Hanalis-Miller T; School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
  • Mikolaskova I; School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
  • Bella V; Institute of Immunology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
  • Mravec B; Department of Clinical Genetics and Department of Mammology, St. Elisabeth Cancer Institute, Bratislava, Slovakia.
  • Hunakova L; Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
Sci Rep ; 12(1): 14666, 2022 08 29.
Article en En | MEDLINE | ID: mdl-36038696
Experimental and clinical studies have shown that the sympathetic nervous system (SNS) stimulates cancer progression and reduces the efficacy of oncological treatment. These effects may be reduced by pharmacological and psychotherapeutical approaches attenuating SNS tone. Therefore, it is necessary to identify those cancer survivors whose sympathetic modulation is excessively increased. For determination of SNS modulation, non-invasive method of heart rate variability (HRV) is widely used. In our study, HRV was determined from 5-min heartbeat recordings in healthy volunteers and in women with benign or malignant breast neoplasias, both in newly diagnosed patients and in women after initial treatment. We showed impaired cardio-vagal regulation in breast cancer patients (linear methods) and also found the increased sympathetic modulation indicated by the non-linear (the symbolic dynamics 0V%) parameter. This non-linear HRV analysis seems to be more sensitive than the linear one, indicating significant differences also in survivors after initial therapy in comparison to healthy controls. The lower sample entropy revealed reduced complexity in heart rate control in both breast cancer survivors groups. These findings suggest that HRV detection represents an inexpensive, easy, and reliable method for identification of those patients with breast cancer whose sympathetic modulation is significantly increased and in which the interventions, aimed at normalizing the balance in the autonomic nervous system (e.g. psychotherapy, biofeedback, treatment by ß-blockers) may be the most effective.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Supervivientes de Cáncer Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Supervivientes de Cáncer Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Reino Unido