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Amyloid deposition in an explanted bioprosthetic aortic valve: case report and review of the literature.
Weerasekare, Jonika M; Zhou, Fang; Skolnick, Adam H; Jilaihawi, Hasan; Williams, Mathew R; Dasari, Surendra; McPhail, Ellen D; Theis, Jason D; Dao, Linda N; Bois, John P; Maleszewski, Joseph J; Bois, Melanie C.
Afiliación
  • Weerasekare JM; Mayo Clinic College of Medicine and Science, Alix School of Medicine, Rochester, MN, USA.
  • Zhou F; Department of Pathology, New York University Langone Health, New York, NY, USA.
  • Skolnick AH; Department of Medicine, Leon H. Charney Division of Cardiology, New York University Health, New York, NY, USA.
  • Jilaihawi H; Department of Cardiothoracic Surgery, New York University Health, New York, NY, USA.
  • Williams MR; Department of Cardiothoracic Surgery, New York University Health, New York, NY, USA.
  • Dasari S; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • McPhail ED; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Theis JD; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Dao LN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Bois JP; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Maleszewski JJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Bois MC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: bois.melanie@mayo.edu.
Cardiovasc Pathol ; 61: 107469, 2022.
Article en En | MEDLINE | ID: mdl-36038051
Herein we present a case of an 80-year-old gentleman who presented with exertional dyspnea status post aortic valve replacement with #23 Trifecta pericardial St. Jude aortic bioprosthetic valve (BV) 12 years prior. He subsequently underwent valve re-replacement due cusp calcification. Histologically, the surgically explanted BV revealed Congophilic deposits with birefringence under cross-polarized light. Extensive work-up identified no systemic source of amyloid in this patient. Liquid chromatography-tandem mass spectrometry-based (LC-MS/MS) proteomics showed the amyloid was composed of human-origin amyloid signature proteins (apolipoprotein A4, apolipoprotein E, serum amyloid P) and human-origin mu heavy chains. Background bovine collagen was also present. Transmission electron microscopy (TEM) showed collections of 7.5-10 nm nonbranching fibrils, consistent with amyloid. Using these techniques, we classified the amyloid as Mu heavy chain, deposition of which is highly unusual in BV. Finally, we provide a review of the literature regarding isolated amyloid deposition in BV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bioprótesis / Prótesis Valvulares Cardíacas Tipo de estudio: Prognostic_studies Límite: Aged80 / Animals / Humans / Male Idioma: En Revista: Cardiovasc Pathol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bioprótesis / Prótesis Valvulares Cardíacas Tipo de estudio: Prognostic_studies Límite: Aged80 / Animals / Humans / Male Idioma: En Revista: Cardiovasc Pathol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos