Renoprotective effects of dapagliflozin in an iron overload non-diabetic rat model.

Firat, Sevde Nur; Kuskonmaz, Serife Mehlika; Çaydere, Muzaffer; Senes, Mehmet; Hücümenoglu, Sema; Çulha, Cavit

Firat, Sevde Nur; Kuskonmaz, Serife Mehlika; Çaydere, Muzaffer; Senes, Mehmet; Hücümenoglu, Sema; Çulha, Cavit.

Afiliación

Firat SN; Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey. Electronic address: sevdenursuruc@yahoo.com.
Kuskonmaz SM; Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey.
Çaydere M; Department of Pathology, Ankara Education and Research Hospital, Ankara, Turkey.
Senes M; Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey.
Hücümenoglu S; Department of Pathology, Ankara Education and Research Hospital, Ankara, Turkey.
Çulha C; Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey.

Adv Med Sci ; 67(2): 311-315, 2022 Sep.

Article en En | MEDLINE | ID: mdl-36037575

RESUMEN

PURPOSE: Sodium glucose co-transporter (SGLT) 2 inhibitors are oral anti-diabetic drugs with proven kidney protective effects. Renal protective effects in non-diabetic individuals have also been shown in recent studies. The aim of this study was to determine the renal protective effects of dapagliflozin by evaluating the oxidative stress markers in the kidney tissue and demonstrating it in renal histological sections in an iron-overloaded rat model. METHODS: A total of 24 Wistar Albino rats were separated into 3 groups of 8 rats. Iron sucrose (60 âmg/kg/day) was administered intraperitoneally to the first group (Group Fe) (n â= â8), iron sucrose and dapagliflozin (0.1 âmg/kg/day) to the second group (Group Fe â+ âD) (n â= â8) and intraperitoneal saline as placebo to the control group (Group C) (n â= â8) for 4 weeks. The glomerular changes were semi-quantitatively scored with Oxford Classification. Oxidative stress was analyzed from the tissue fluorescent oxidation product (FLOP), malondialdehyde (MDA) and total sulfhydryl (T-SH) levels. RESULTS: Dapagliflozin prevented glomerular and mesangial damage of iron overload in the non-diabetic rat model. MDA levels were significantly higher in Group Fe compared to the Group C, and there was no significant difference between the Fe â+ âD group and Group C. T-SH levels were preserved in the Fe â+ âD group and were significantly higher than in the Fe group. CONCLUSIONS: The results of this study showed that dapagliflozin helped preserve the glomerular and mesangial structure histologically and reduced oxidative stress markers in a non-diabetic iron overload rat model.

Asunto(s)

Sobrecarga de Hierro; Enfermedades Renales; Inhibidores del Cotransportador de Sodio-Glucosa 2; Simportadores; Animales; Ratas; Sacarato de Óxido Férrico/farmacología; Ratas Wistar; Inhibidores del Cotransportador de Sodio-Glucosa 2/farmacología; Inhibidores del Cotransportador de Sodio-Glucosa 2/uso terapéutico; Sobrecarga de Hierro/tratamiento farmacológico; Estrés Oxidativo; Enfermedades Renales/tratamiento farmacológico; Malondialdehído; Glucosa/farmacología; Hierro; Simportadores/farmacología; Sodio/farmacología

Palabras clave

Dapagliflozine; Non-diabetic rat; Oxidative stress; Renoprotective effect

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrecarga de Hierro / Simportadores / Inhibidores del Cotransportador de Sodio-Glucosa 2 / Enfermedades Renales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Adv Med Sci Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google