Cancer-driving mutations are enriched in genic regions intolerant to germline variation.

Vitsios, Dimitrios; Dhindsa, Ryan S; Matelska, Dorota; Mitchell, Jonathan; Zou, Xuequing; Armenia, Joshua; Hu, Fengyuan; Wang, Quanli; Sidders, Ben; Harper, Andrew R; Petrovski, Slavé

Vitsios, Dimitrios; Dhindsa, Ryan S; Matelska, Dorota; Mitchell, Jonathan; Zou, Xuequing; Armenia, Joshua; Hu, Fengyuan; Wang, Quanli; Sidders, Ben; Harper, Andrew R; Petrovski, Slavé.

Afiliación

Vitsios D; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Dhindsa RS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.
Matelska D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Mitchell J; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA.
Zou X; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Armenia J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Hu F; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Wang Q; Bioinformatics and Data Science, Research, and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
Sidders B; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Harper AR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.
Petrovski S; Bioinformatics and Data Science, Research, and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.

Sci Adv ; 8(34): eabo6371, 2022 08 26.

Article en En | MEDLINE | ID: mdl-36026442

Asunto(s)

Mutación de Línea Germinal; Neoplasias Hematológicas; Células Germinativas; Neoplasias Hematológicas/genética; Humanos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mutación de Línea Germinal / Neoplasias Hematológicas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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