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Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity.
Arputhasamy, Cyrene; Foulger, Anna C; Lucanic, Mark; Rane, Anand; Schmidt, Minna; Garrett, Theo; Broussalian, Michael; Battistoni, Elena; Brem, Rachel B; Lithgow, Gordon J; Chamoli, Manish; Andersen, Julie K.
Afiliación
  • Arputhasamy C; Buck Institute for Research On Aging, Novato, CA, USA.
  • Foulger AC; Buck Institute for Research On Aging, Novato, CA, USA.
  • Lucanic M; Buck Institute for Research On Aging, Novato, CA, USA.
  • Rane A; Buck Institute for Research On Aging, Novato, CA, USA.
  • Schmidt M; Buck Institute for Research On Aging, Novato, CA, USA.
  • Garrett T; School of Gerontology, USC Leonard Davis, University of Southern California, Los Angeles, CA, USA.
  • Broussalian M; Buck Institute for Research On Aging, Novato, CA, USA.
  • Battistoni E; Buck Institute for Research On Aging, Novato, CA, USA.
  • Brem RB; Dominican University of California, San Rafael, CA, USA.
  • Lithgow GJ; Buck Institute for Research On Aging, Novato, CA, USA.
  • Chamoli M; Dominican University of California, San Rafael, CA, USA.
  • Andersen JK; Buck Institute for Research On Aging, Novato, CA, USA.
Geroscience ; 45(2): 1237-1245, 2023 04.
Article en En | MEDLINE | ID: mdl-36018536
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an FDA approved drug sodium polystyrene sulfonate (SPS), used to reduce high blood potassium in humans, enhances lysosomal function both in C. elegans and in human neuronal cells. Enhanced lysosomal function following SPS treatment is accompanied by the suppression of proteotoxicity caused by expression of the neurotoxic peptides Aß and TAU. Additionally, treatment with SPS imparts health benefits as it significantly increases lifespan in C. elegans. Overall our work supports the potential use of SPS as a prospective geroprotective intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potasio / Caenorhabditis elegans Límite: Animals / Humans Idioma: En Revista: Geroscience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potasio / Caenorhabditis elegans Límite: Animals / Humans Idioma: En Revista: Geroscience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza