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Optimization of Nanosubstrates toward Molecularly Surface-Functionalized Raman Spectroscopy.
De Carvalho Gomes, Paulo; Hardy, Mike; Tagger, Yazmin; Rickard, Jonathan James Stanley; Mendes, Paula; Oppenheimer, Pola Goldberg.
Afiliación
  • De Carvalho Gomes P; School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
  • Hardy M; School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
  • Tagger Y; School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
  • Rickard JJS; Department of Physics, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, U.K.
  • Mendes P; School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
  • Oppenheimer PG; School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
J Phys Chem C Nanomater Interfaces ; 126(32): 13774-13784, 2022 Aug 18.
Article en En | MEDLINE | ID: mdl-36017358
Diagnostic advancements require continuous developments of reliable analytical sensors, which can simultaneously fulfill many criteria, including high sensitivity and specificity for a broad range of target analytes. Incorporating the highly sensitive attributes of surface-enhanced Raman spectroscopy (SERS) combined with highly specific analyte recognition capabilities via molecular surface functionalization could address major challenges in molecular diagnostics and analytical spectroscopy fields. Herein, we have established a controllable molecular surface functionalization process for a series of textured gold surfaces. To create the molecularly surface-functionalized SERS platforms, self-assembled benzyl-terminated and benzoboroxole-terminated monolayers were used to compare which thicknesses and root-mean-square (RMS) roughness of planar gold produced the most sensitive and specific surfaces. Optimal functionalization was identified at 80 ± 8 nm thickness and 7.2 ± 1.0 nm RMS. These exhibited a considerably higher SERS signal (70-fold) and improved sensitivity for polysaccharides when analyzed using principal component analysis (PCA) and self-organizing maps (SOM). These findings lay the procedure for establishing the optimal substrate specifications as an essential prerequisite for future studies aiming at developing the feasibility of molecular imprinting for SERS diagnostic applications and the subsequent delivery of advanced, highly selective, and sensitive sensing devices and analytical platforms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Phys Chem C Nanomater Interfaces Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Phys Chem C Nanomater Interfaces Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos