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Homologous or Heterologous COVID-19 Booster Regimens Significantly Impact Sero-Neutralization of SARS-CoV-2 Virus and Its Variants.
Buathong, Rome; Hunsawong, Taweewun; Wacharapluesadee, Supaporn; Guharat, Suriya; Jirapipatt, Ratthapat; Ninwattana, Sasiprapa; Thippamom, Nattakarn; Jitsatja, Anusara; Jones, Anthony R; Rungrojchareonkit, Kamonthip; Lohachanakul, Jindarat; Suthangkornkul, Rungarun; Tayong, Kedsara; Klungthong, Chonticha; Fernandez, Stefan; Putcharoen, Opass.
Afiliación
  • Buathong R; Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.
  • Hunsawong T; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Wacharapluesadee S; Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Guharat S; Samut Sakhon Provincial Health Office, Ministry of Public Health, Nonthaburi 11000, Thailand.
  • Jirapipatt R; Samut Sakhon Provincial Health Office, Ministry of Public Health, Nonthaburi 11000, Thailand.
  • Ninwattana S; Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Thippamom N; Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
  • Jitsatja A; Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Jones AR; Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
  • Rungrojchareonkit K; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Lohachanakul J; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Suthangkornkul R; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Tayong K; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Klungthong C; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Fernandez S; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  • Putcharoen O; Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.
Vaccines (Basel) ; 10(8)2022 Aug 15.
Article en En | MEDLINE | ID: mdl-36016209
We determined the levels of neutralizing antibodies against the SARS-CoV-2 ancestral strain, Delta and Omicron variants of concern (VOCs), in 125 healthcare workers who received CoronaVac as their primary vaccination and later received either a single ChAdOx1 or a combi-nation of two consecutive boosters using either two ChAdOx1 doses or a ChAdOx1 or BNT162b2 as the primary and second boosters, respectively, or two doses of BNT162b2. The titers 12 weeks after primary vaccination were inadequate to neutralize all strains. After a single ChAdOx1 booster, the levels of neutralization at Day 30 varied significantly, with only a small proportion of participants developing neutralizing titers against Omicron at Day 7 and 30. The two doses of ChAdOx1 as the booster induced the lowest activity. A combination ChAdOx1 and BNT162b2 induced greater neutralization than by two doses of ChAdOx1. Two doses of BNT162b2 as the booster had the maximal activity against Omicron VOC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza