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Phytochemical Screening, Anti-Inflammatory, and Antidiabetic Activities of Different Extracts from Caralluma edulis Plant.
Khan, Maria; Manzoor, Zahid; Rafiq, Muhammad; Munawar, Shaukat Hussain; Waqas, Muhammad Yasir; Majeed, Hamid; Ali Shah, Syed Zahid; Hussain, Riaz; Hussain, Hafiz Iftikhar; Tahir, Tehreem; Kotwica-Mojzych, Katarzyna; Mojzych, Mariusz.
Afiliación
  • Khan M; Department of Physiology and Biochemistry, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Manzoor Z; Department of Pharmacology and Toxicology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Rafiq M; Department of Physiology and Biochemistry, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Munawar SH; Department of Pharmacology and Toxicology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Waqas MY; Department of Physiology and Biochemistry, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Majeed H; Department of Food Science and Technology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Ali Shah SZ; Department of Pathology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
  • Hussain R; Department of Pathology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
  • Hussain HI; Department of Pathology, Faculty of Veterinary Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
  • Tahir T; Institute of Biochemistry, Biotechnology and Bioinformatics, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
  • Kotwica-Mojzych K; Laboratory of Experimental Cytology, Medical Faculty, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland.
  • Mojzych M; Department of Chemistry, Siedlce University of Natural Sciences and Humanities, 08-110 Siedlce, Poland.
Molecules ; 27(16)2022 Aug 22.
Article en En | MEDLINE | ID: mdl-36014583
The plant Caralluma edulis is traditionally used against diabetes and inflammatory conditions in Pakistan. This study was designed to provide scientific validation of the traditional use of Caralluma edulis. Phytochemicals were extracted from the plant by different solvents (distilled water, methanol, ethanol, and acetone) using the Soxhlet's extraction method. Bioactive compounds were detected by gas chromatography-mass spectrometry (GC-MS). The in vitro anti-inflammatory activities (albumin denaturation, membrane stabilization, and proteinase inhibition) and antioxidant capacity (DPPH scavenging activity, FRAP reducing activity) of different extracts from Caralluma edulis were assessed. The antidiabetic potential of Caralluma edulis plant extracts was determined in acute and subacute diabetic rabbit models. Oxidative stress and enzymatic antioxidant status were also estimated in MDA, CAT, and SOD levels. Results showed that the methanol extract yielded the highest contents of phenolics, flavonoids, alkaloids, and terpenoids. The in vitro anti-inflammatory activity and antioxidant potential of the methanol extract were the highest among the tested solvents. The tested extracts did not show any remarkable antidiabetic activity in the acute diabetic model. However, all tested extracts demonstrated antidiabetic potential in the subacute diabetic model. No adverse effect was observed at the tested dose (200 mg/kg) of Caralluma edulis extracts in experimental animals. It is concluded that methanol is the key solvent for extracting bioactive compounds from Caralluma edulis. The plant can be used against inflammatory disorders and may prove a potential candidate for drug development. Long-term use of Caralluma edulis at the tested dose (200 mg/kg) showed antidiabetic properties in the animal model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apocynaceae / Diabetes Mellitus Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apocynaceae / Diabetes Mellitus Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza