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Association between Galectin Levels and Neurodegenerative Diseases: Systematic Review and Meta-Analysis.
Ramos-Martínez, Edgar; Ramos-Martínez, Iván; Sánchez-Betancourt, Iván; Ramos-Martínez, Juan Carlos; Peña-Corona, Sheila Irais; Valencia, Jorge; Saucedo, Renata; Almeida-Aguirre, Ericka Karol Pamela; Cerbón, Marco.
Afiliación
  • Ramos-Martínez E; Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán 04510, Mexico.
  • Ramos-Martínez I; Departamento de Medicina y Zootecnia de Cerdos, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Coyoacán 04510, Mexico.
  • Sánchez-Betancourt I; Departamento de Medicina y Zootecnia de Cerdos, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Coyoacán 04510, Mexico.
  • Ramos-Martínez JC; Departamento de Cardiología, Hospital General Regional Lic Ignacio Garcia Tellez IMSS, Cuauhtémoc 97150, Mexico.
  • Peña-Corona SI; Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán 04510, Mexico.
  • Valencia J; Unidad de Investigación en Endocrinología, UMAE Hospital de Especialidades, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720, Mexico.
  • Saucedo R; Unidad de Investigación en Endocrinología, UMAE Hospital de Especialidades, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720, Mexico.
  • Almeida-Aguirre EKP; Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán 04510, Mexico.
  • Cerbón M; Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología "Isidro Espinosa de los Reyes"-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Biomolecules ; 12(8)2022 07 31.
Article en En | MEDLINE | ID: mdl-36008956
Galectins are a family of proteins with an affinity for ß-galactosides that have roles in neuroprotection and neuroinflammation. Several studies indicate that patients with neurodegenerative diseases have alterations in the concentration of galectins in their blood and brain. However, the results of the studies are contradictory; hence, a meta-analysis is performed to clarify whether patients with neurodegenerative diseases have elevated galectin levels compared to healthy individuals. Related publications are obtained from the databases: PubMed, Central-Conchrane, Web of Science database, OVID-EMBASE, Scope, and EBSCO host until February 2022. A pooled standard mean difference (SMD) with a 95% confidence interval (CI) is calculated by fixed-effect or random-effect model analysis. In total, 17 articles are included in the meta-analysis with a total of 905 patients. Patients with neurodegenerative diseases present a higher level of galectin expression compared to healthy individuals (MDS = 0.70, 95% CI 0.28-1.13, p = 0.001). In the subgroup analysis by galectin type, a higher galectin-3 expression is observed in patients with neurodegenerative diseases. Patients with Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALD), and Parkinson's disease (PD) expressed higher levels of galectin-3. Patients with multiple sclerosis (MS) have higher levels of galectin-9. In conclusion, our meta-analysis shows that patients with neurovegetative diseases have higher galectin levels compared to healthy individuals. Galectin levels are associated with the type of disease, sample, detection technique, and region of origin of the patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer / Esclerosis Amiotrófica Lateral Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Biomolecules Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer / Esclerosis Amiotrófica Lateral Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Biomolecules Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza