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Late evening snack and oral amino acid capsules improved respiratory quotient and Fischer ratio in patients with alcoholic liver cirrhosis.
Zhao, Juan; Wu, Jing; Li, Juan; Wang, Zhong-Ying; Meng, Qing-Hua.
Afiliación
  • Zhao J; Second Department of Liver Disease Centre, Beijing Youan Hospital, Capital MedicalUniversity, Beijing, 100069, China.
  • Wu J; Department of Medical Oncology, Beijing Youan Hospital(,) Capital Medical University(,) Beijing, 100069, China.
  • Li J; Department of Respiratory and Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
  • Wang ZY; Department of Respiratory and Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
  • Meng QH; Department of Medical Oncology, Beijing Youan Hospital(,) Capital Medical University(,) Beijing, 100069, China. Electronic address: meng_qh0805@ccmu.edu.cn.
Ann Hepatol ; 28(4): 100750, 2023.
Article en En | MEDLINE | ID: mdl-36007871
INTRODUCTION AND OBJECTIVES: Appropriate nutritional support may improve energy metabolism in alcoholic liver cirrhosis (ALC) patients. We explored the effect of a late evening snack (LES) and oral amino acid (OAA) capsules on energy metabolism and the Fischer ratio in ALC. PATIENTS AND METHODS: Ninety-one ALC patients were enrolled and randomly divided into three groups: 31 patients in the LES and OAA group, 32 in the LES group, and 28 controls. Respiratory quotient (RQ), carbohydrate oxidation rate (CHO%), fat oxidation rate (FAT%), serum isoleucine and the Fischer ratio were measured at baseline and at months 1, 3, and 6 of follow-up. RESULTS: The RQ in the LES and OAA group was 0.79 ± 0.06, 0.80 ± 0.04, 0.82 ± 0.04, and 0.82 ± 0.04 at baseline and at months 1, 3, and 6 of follow-up, respectively. These values were significantly higher than those in the LES group (P < 0.05). The RQ in the LES group was significantly higher than that in the control group at month 1 and month 6 (P < 0.05). CHO% in the LES and OAA group was significantly increased and FAT% was significantly decreased at month 3 of follow-up (P < 0.05). In the LES and OAA group, serum isoleucine and the Fischer ratio were markedly increased compared with the LES group and control group (P < 0.05). CONCLUSIONS: LES can significantly increase the RQ in ALC. LES and OAA were more effective than LES alone in improving serum isoleucine and the Fischer ratio.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoácidos / Cirrosis Hepática Alcohólica Límite: Humans Idioma: En Revista: Ann Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: México
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoácidos / Cirrosis Hepática Alcohólica Límite: Humans Idioma: En Revista: Ann Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: México