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Genomic features of mecA-positive methicillin-resistant Mammaliicoccus sciuri causing fatal infections in pets admitted to a veterinary intensive care unit.
Sacramento, Andrey G; Fuga, Bruna; Monte, Daniel F M; Cardoso, Brenda; Esposito, Fernanda; Dolabella, Silvio S; Barbosa, Ana A T; Zanella, Rosemeire C; Cortopassi, Silvia R G; da Silva, Luciano C B A; Lincopan, Nilton; Sellera, Fábio P.
Afiliación
  • Sacramento AG; Department of Morphology, Federal University of Sergipe, São Cristóvão, Brazil. Electronic address: andreysacramento@gmail.com.
  • Fuga B; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil.
  • Monte DFM; Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, Food Research Center, University of São Paulo, São Paulo, Brazil; Laboratory of Avian Pathology, Department of Pathology, Theriogenology, and One Health, Sao Paulo State University (FCAV-Unesp), Jaboticabal, São Paulo
  • Cardoso B; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Esposito F; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil.
  • Dolabella SS; Department of Morphology, Federal University of Sergipe, São Cristóvão, Brazil.
  • Barbosa AAT; Department of Morphology, Federal University of Sergipe, São Cristóvão, Brazil.
  • Zanella RC; Bacteriology Branch, Instituto Adolfo Lutz, São Paulo, Brazil.
  • Cortopassi SRG; Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • da Silva LCBA; Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil; School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil.
  • Lincopan N; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil.
  • Sellera FP; School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil; Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil. Electronic address: fsellera@usp.br.
Microb Pathog ; 171: 105733, 2022 Oct.
Article en En | MEDLINE | ID: mdl-36002114
Methicillin-resistant staphylococci have become leading cause of infectious diseases in humans and animals, being categorized as high priority pathogens by the World Health Organization. Although methicillin-resistant Staphylococcus sciuri (recently moved to Mammaliicoccus sciuri) has been widely reported in companion animals, there is scarce information regarding their clinical impact and genomic features. Herein, we reported the occurrence and genomic characteristics of methicillin-resistant M. sciuri recovered from fatal infections in pets admitted to an intensive care unit of a veterinary hospital, in Brazil. Two M. sciuri strains were isolated from bronchoalveolar lavage samples collected from dog (strain SS01) and cat (strain SS02) presenting with sepsis and acute respiratory distress syndrome. Both isolates displayed a multidrug-resistant profile, whereas whole-genome sequencing analysis confirmed the presence of the mecA gene, along to genetic determinant conferring resistance to macrolides, streptogramins, aminoglycosides, and trimethoprim. For both strains, the mec and crr gene complex shared high identity (≥97%) with analogue sequences from a M. sciuri isolated from a human wound infection, in the Czech Republic. Strains were assigned to the sequence type ST52 and the novel ST74. Phylogenomic analysis revealed a broad host range association of these strains with several hosts and sources, including humans, animals, food, and the environment through different years and geographic locations. Our findings demonstrate that infections caused by mecA-positive M. sciuri strains can be a serious threat for veterinary intensive care patients and the medical staff, with additional implications for One Health approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Límite: Animals / Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Límite: Animals / Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido