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A New Detergent for the Effective Decellularization of Bovine and Porcine Pericardia.
Todesco, Martina; Imran, Saima Jalil; Fortunato, Tiago Moderno; Sandrin, Deborah; Borile, Giulia; Romanato, Filippo; Casarin, Martina; Giuggioli, Germana; Conte, Fabio; Marchesan, Massimo; Gerosa, Gino; Bagno, Andrea.
Afiliación
  • Todesco M; Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy.
  • Imran SJ; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Fortunato TM; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Sandrin D; Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
  • Borile G; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Romanato F; Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
  • Casarin M; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Giuggioli G; Department of Physics and Astronomy 'G. Galilei', University of Padova, Via Marzolo 8, 35131 Padova, Italy.
  • Conte F; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Marchesan M; Department of Physics and Astronomy 'G. Galilei', University of Padova, Via Marzolo 8, 35131 Padova, Italy.
  • Gerosa G; L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani 2, 35128 Padova, Italy.
  • Bagno A; Department of Physics and Astronomy 'G. Galilei', University of Padova, Via Marzolo 8, 35131 Padova, Italy.
Biomimetics (Basel) ; 7(3)2022 Aug 01.
Article en En | MEDLINE | ID: mdl-35997424
Human and animal pericardia are among the most widely exploited materials suitable to repair damaged tissues in the cardiovascular surgery context. Autologous, xenogeneic (chemically treated) and homologous pericardia are largely utilized, but they do exhibit some crucial drawbacks. Any tissue treated with glutaraldehyde is known to be prone to calcification in vivo, lacks regeneration potential, has limited durability, and can result in cytotoxicity. Moreover, autologous tissues have limited availability. Decellularized biological tissues represent a promising alternative: decellularization removes cellular and nuclear components from native tissues and makes them suitable for repopulation by autologous cells upon implantation into the body. The present work aims to assess the effects of a new detergent, i.e., Tergitol, for decellularizing bovine and porcine pericardia. The decellularization procedure successfully removed cells, while preserving the histoarchitecture of the extracellular matrix. No cytotoxic effect was observed. Therefore, decellularized pericardia showed potential to be used as scaffold for cardiovascular tissue regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomimetics (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomimetics (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza