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Updated full range of Eliciting Dose values for Cow's milk for use in food allergen risk assessment.
Blom, W Marty; Westerhout, Joost; Baumert, Joseph L; Meima, Marie Y; Turner, Paul J; Ebisawa, Motohiro; Yanagida, Noriyuki; Remington, Benjamin C; Houben, Geert F.
Afiliación
  • Blom WM; The Netherlands Organization for Applied Scientific Research TNO, Princetonlaan 6, 3584 CB, Utrecht, the Netherlands. Electronic address: marty.blom@tno.nl.
  • Westerhout J; The Netherlands Organization for Applied Scientific Research TNO, Princetonlaan 6, 3584 CB, Utrecht, the Netherlands.
  • Baumert JL; Food Allergy Research and Resources Program, University of Nebraska, Lincoln, Food Innovation Center, 1901 N 21 Street, PO Box 886207, USA.
  • Meima MY; The Netherlands Organization for Applied Scientific Research TNO, Princetonlaan 6, 3584 CB, Utrecht, the Netherlands.
  • Turner PJ; National Heart & Lung Institute, Imperial College London, London, United Kingdom.
  • Ebisawa M; National Hospital Organization, Sagamihara National Hospital, 18-1, Sakuradai, Minami-ku Sagamihara, Kanagawa, 252-0392, Japan.
  • Yanagida N; National Hospital Organization, Sagamihara National Hospital, 18-1, Sakuradai, Minami-ku Sagamihara, Kanagawa, 252-0392, Japan.
  • Remington BC; Food Allergy Research and Resources Program, University of Nebraska, Lincoln, Food Innovation Center, 1901 N 21 Street, PO Box 886207, USA.
  • Houben GF; The Netherlands Organization for Applied Scientific Research TNO, Princetonlaan 6, 3584 CB, Utrecht, the Netherlands.
Food Chem Toxicol ; 168: 113381, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35995077
Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original dataset. Using the Stacked Model Averaging statistical method for interval-censored data on the 697 individual NOAELs and LOAELs for milk generated an updated full ED distribution. The ED01 and ED05, the doses at which 1% and 5% of the milk-allergic population would be predicted to experience any objective allergic reaction, were 0.3 and 3.2 mg milk protein for the discrete and 0.4 mg and 4.3 mg milk protein for the cumulative dose distribution, respectively. These values are slightly higher but remain within the 95% confidence interval of previously published EDs. We recommend using the updated EDs for future characterization of risks of exposure of milk-allergic individuals to milk protein. This paper contributes to the discussion on the Reference Dose for milk in the recent Ad hoc Joint FAO/WHO Expert Consultation on Risk Assessment of Food Allergens. It will also benefit harmonization of food allergen risk assessment and risk management globally.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad a la Leche / Hipersensibilidad a los Alimentos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad a la Leche / Hipersensibilidad a los Alimentos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido