Your browser doesn't support javascript.
loading
Real-World Investigation on Anticoagulation Management Before and After Catheter Ablation for Atrial Fibrillation in Japan　- Periprocedural and Long-Term Outcomes.
Nogami, Akihiko; Soejima, Kyoko; Morishima, Itsuro; Hiroshima, Kenichi; Kato, Ritsushi; Sakagami, Satoru; Miura, Fumiharu; Okawa, Keisuke; Kimura, Tetsuya; Inoue, Takashi; Takita, Atsushi; Uno, Kikuya; Kumagai, Koichiro; Kurita, Takashi; Gosho, Masahiko; Aonuma, Kazutaka.
Afiliación
  • Nogami A; Department of Cardiology, Faculty of Medicine, University of Tsukuba.
  • Soejima K; Department of Cardiology, Kyorin University School of Medicine.
  • Morishima I; Department of Cardiology, Ogaki Municipal Hospital.
  • Hiroshima K; Cardiovascular Division, Kokura Memorial Hospital.
  • Kato R; Department of Arrhythmia, Saitama Medical University International Medical Center.
  • Sakagami S; Department of Cardiology, National Hospital Organization Kanazawa Medical Center.
  • Miura F; Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital.
  • Okawa K; Department of Cardiovascular Medicine, Kagawa Prefectural Central Hospital.
  • Kimura T; Primary Medical Science Department, DAIICHI SANKYO Co., Ltd.
  • Inoue T; Primary Medical Science Department, DAIICHI SANKYO Co., Ltd.
  • Takita A; Data Intelligence Department, DAIICHI SANKYO Co., Ltd.
  • Uno K; Heart Rhythm Center, Tokyo Heart Rhythm Hospital.
  • Kumagai K; Heart Rhythm Center, Fukuoka Sanno Hospital.
  • Kurita T; Division of Cardiovascular Center, Kindai University School of Medicine.
  • Gosho M; Department of Biostatistics, Faculty of Medicine, University of Tsukuba.
  • Aonuma K; Department of Cardiology, Faculty of Medicine, University of Tsukuba.
Circ J ; 87(1): 50-62, 2022 12 23.
Article en En | MEDLINE | ID: mdl-35989303
BACKGROUND: Optimal periprocedural oral anticoagulant (OAC) therapy before catheter ablation (CA) for atrial fibrillation (AF) and the safety profile of OAC discontinuation during the remote period (from 31 days and up to 1 year after CA) have not been well defined.Methods and Results: The RYOUMA registry is a prospective multicenter observational study of Japanese patients who underwent CA for AF in 2017-2018. Of the 3,072 patients, 82.3% received minimally interrupted direct-acting OACs (DOACs) and 10.2% received uninterrupted DOACs. Both uninterrupted and minimally interrupted DOACs were associated with an extremely low thromboembolic event rate. Female, long-standing persistent AF, low creatinine clearance, hepatic disorder, and high intraprocedural heparin dose were independent factors associated with periprocedural major bleeding. At 1 year after CA, DOAC was continued in 55.9% of patients and warfarin in 56.4%. The incidence of thromboembolic and major bleeding events for 1 year was 0.3% and 1.2%, respectively. Age ≥73 years, dementia, and AF recurrence were independently associated with major bleeding events. Univariate analyses revealed that warfarin continuation and off-label overdose of DOACs were risk factors for major bleeding after CA. CONCLUSIONS: High intraprocedural dose of heparin was associated with periprocedural major bleeding events. At 1 year after CA, over half of the patients had continued OAC therapy. Thromboembolic events were extremely low; however, major bleeding occurred in 1.2%. Age ≥73 years, dementia, and AF recurrence were independently associated with major bleeding after CA.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Tromboembolia / Ablación por Catéter / Demencia Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Tromboembolia / Ablación por Catéter / Demencia Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Japón