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Longitudinal investigation of suicidal ideation and associated factors during pediatric acute lymphoblastic leukemia chemotherapy.
Raghubar, Kimberly P; Chambers, Tiffany; Hill, Ryan M; Taylor, Olga; Hockenberry, Marilyn; Hooke, M Casey; Mitby, Pauline; Moore, Ida Ki; Brown, Austin L; Scheurer, Michael E.
Afiliación
  • Raghubar KP; Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.
  • Chambers T; Department of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
  • Hill RM; Department of Psychology, College for Health, Community and Policy, University of Texas at San Antonio, San Antonio, Texas, USA.
  • Taylor O; Department of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
  • Hockenberry M; Department of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
  • Hooke MC; School of Nursing, University of Minnesota, Minneapolis, Minnesota, USA.
  • Mitby P; Children's Minnesota Cancer and Blood Disorders Program, Minneapolis, Minnesota, USA.
  • Moore IK; Children's Minnesota Cancer and Blood Disorders Program, Minneapolis, Minnesota, USA.
  • Brown AL; Department of Nursing, University of Arizona, Tuscan, Arizona, USA.
  • Scheurer ME; Department of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
Psychooncology ; 31(10): 1782-1789, 2022 10.
Article en En | MEDLINE | ID: mdl-35986586
OBJECTIVE: This study describes the prevalence of suicidal ideation (SI) during acute lymphoblastic leukemia (ALL) therapy and investigates the influence of clinical factors and physical symptoms on SI. METHODS: The Children's Depressive Inventory (CDI-2) was administered to ALL patients (diagnosed 2012-2017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi-site study. SI was present if patients endorsed the item "I want to kill myself." Logistic regression models evaluated associations between SI and sociodemographic factors; depressive symptoms; and below average, average, and above average symptom clusters identified using latent class analysis of pain, nausea, fatigue, and sleep. RESULTS: Participants (n = 175) were 51% male, 75% high-/very high-risk disease, with a median age of 11.2 years at diagnosis (range: 7-18 years). Overall, 14.9% of patients (75% under age 12 years) endorsed SI during treatment, including 4% at start of consolidation, 9% at DI, 8% at MC1, and 4% at MC2. Non-Hispanic Other patients were 10.9-times (95% CI: 2.30-53.40) more likely than non-Hispanic Whites to endorse SI (p = 0.003). The frequency of SI was higher in patients experiencing above average (53.3%) compared to below average (4.1%, p = 0.003) symptoms. Depressive symptoms were consistently associated with SI. CONCLUSIONS: SI during the initial year of childhood ALL was more prevalent in children under the age of 12 years, from ethnic groups not typically associated with increased risk, and who endorsed increased physical and depressive symptoms. Findings highlight the need for improved screening of mental health problems to mitigate symptoms of distress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Ideación Suicida Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychooncology Asunto de la revista: NEOPLASIAS / PSICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Ideación Suicida Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychooncology Asunto de la revista: NEOPLASIAS / PSICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido