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Insular functional connectivity in migraine with aura.
Gollion, Cédric; Lerebours, Fleur; Nemmi, Federico; Arribarat, Germain; Bonneville, Fabrice; Larrue, Vincent; Péran, Patrice.
Afiliación
  • Gollion C; Department of Neurology, University Hospital of Toulouse, 31059 cedex 9, Toulouse, France. gollion.c@chu-toulouse.fr.
  • Lerebours F; Toulouse NeuroImaging Center, ToNIC, University of Toulouse III, Inserm, Toulouse, France. gollion.c@chu-toulouse.fr.
  • Nemmi F; Department of Neurology, University Hospital of Toulouse, 31059 cedex 9, Toulouse, France.
  • Arribarat G; Toulouse NeuroImaging Center, ToNIC, University of Toulouse III, Inserm, Toulouse, France.
  • Bonneville F; Toulouse NeuroImaging Center, ToNIC, University of Toulouse III, Inserm, Toulouse, France.
  • Larrue V; Toulouse NeuroImaging Center, ToNIC, University of Toulouse III, Inserm, Toulouse, France.
  • Péran P; Department of Neuroradiology, University Hospital of Toulouse, Toulouse, France.
J Headache Pain ; 23(1): 106, 2022 Aug 19.
Article en En | MEDLINE | ID: mdl-35982396
INTRODUCTION: Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions. This study aimed at investigating functional connectivity of insula subregions in MA. METHODS: Twenty-one interictal patients with MA were compared to 18 healthy controls (HC) and 12 interictal patients with migraine without aura (MO) and were scanned with functional MRI during the resting state. Functional coupling of the insula was comprehensively tested with 12 seeds located in the right and left, dorsal, middle, ventral, anterior and posterior insula, by using a seed-to-voxel analysis. RESULTS: Seed-to-voxel analysis revealed, in MA, a strong functional coupling of the right and left antero-dorsal insula with clusters located in the upper cerebellum. The overlap of these cerebellar clusters corresponded to the vermis VI. These functional couplings were not correlated to duration of MA, frequency of MA attacks nor time since last MA attack, and were not found in MO. DISCUSSION: The anterior insula and superior cerebellum, including vermis VI, are components of the central Autonomic Nervous System (ANS) network. As these regions are involved in the control of cardiovascular parasympathetic tone, we hypothesize that this connectivity may reflect the cardiovascular features of MA. CONCLUSION: The anterior dorsal insula is connected with vermis VI in MA patients in the resting state. This connectivity may reflect the cardiovascular features of MA. TRIAL REGISTRATION: NCT02708797.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Migraña con Aura / Epilepsia / Trastornos Migrañosos Límite: Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Migraña con Aura / Epilepsia / Trastornos Migrañosos Límite: Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido