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Emerging role of lncRNAs in drug resistance mechanisms in head and neck squamous cell carcinoma.
Peña-Flores, José A; Bermúdez, Mercedes; Ramos-Payán, Rosalío; Villegas-Mercado, Carlos E; Soto-Barreras, Uriel; Muela-Campos, Daniela; Álvarez-Ramírez, Alexis; Pérez-Aguirre, Brenda; Larrinua-Pacheco, Ana D; López-Camarillo, César; López-Gutiérrez, Jorge A; Garnica-Palazuelos, Julio; Estrada-Macías, Marvin E; Cota-Quintero, Juan L; Barraza-Gómez, Andrés A.
Afiliación
  • Peña-Flores JA; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Bermúdez M; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Ramos-Payán R; Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Mexico.
  • Villegas-Mercado CE; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Soto-Barreras U; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Muela-Campos D; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Álvarez-Ramírez A; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Pérez-Aguirre B; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Larrinua-Pacheco AD; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • López-Camarillo C; Autonomous University of Mexico City, Mexico City, Mexico.
  • López-Gutiérrez JA; Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Mexico.
  • Garnica-Palazuelos J; Faculty of Biology, Autonomous University of Sinaloa, Culiacán, Mexico.
  • Estrada-Macías ME; Faculty of Odontology , Autonomous University of Sinaloa, Culiacán, Mexico.
  • Cota-Quintero JL; Faculty of Odontology, Autonomous University of Chihuahua, Chihuahua, Mexico.
  • Barraza-Gómez AA; Faculty of Biology, Autonomous University of Sinaloa, Culiacán, Mexico.
Front Oncol ; 12: 965628, 2022.
Article en En | MEDLINE | ID: mdl-35978835
Head and neck squamous cell carcinoma (HNSCC) originates in the squamous cell lining the mucosal surfaces of the head and neck region, including the oral cavity, nasopharynx, tonsils, oropharynx, larynx, and hypopharynx. The heterogeneity, anatomical, and functional characteristics of the patient make the HNSCC a complex and difficult-to-treat disease, leading to a poor survival rate and a decreased quality of life due to the loss of important physiologic functions and aggressive surgical injury. Alteration of driver-oncogenic and tumor-suppressing lncRNAs has recently been recently in HNSCC to obtain possible biomarkers for diagnostic, prognostic, and therapeutic approaches. This review provides current knowledge about the implication of lncRNAs in drug resistance mechanisms in HNSCC. Chemotherapy resistance is a major therapeutic challenge in HNSCC in which lncRNAs are implicated. Lately, it has been shown that lncRNAs involved in autophagy induced by chemotherapy and epithelial-mesenchymal transition (EMT) can act as mechanisms of resistance to anticancer drugs. Conversely, lncRNAs involved in mesenchymal-epithelial transition (MET) are related to chemosensitivity and inhibition of invasiveness of drug-resistant cells. In this regard, long non-coding RNAs (lncRNAs) play a pivotal role in both processes and are important for cancer detection, progression, diagnosis, therapy response, and prognostic values. As the involvement of more lncRNAs is elucidated in chemoresistance mechanisms, an improvement in diagnostic and prognostic tools could promote an advance in targeted and specific therapies in precision oncology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza