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A comparison of outcomes after lung transplantation between European and North American centers.
Yang, Zhizhou; Takahashi, Tsuyoshi; Terada, Yuriko; Meyers, Bryan F; Kozower, Benjamin D; Patterson, G Alexander; Nava, Ruben G; Hachem, Ramsey R; Witt, Chad A; Byers, Derek E; Kulkarni, Hrishikesh S; Guillamet, Rodrigo Vazquez; Yan, Yan; Chang, Su-Hsin; Kreisel, Daniel; Puri, Varun.
Afiliación
  • Yang Z; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Takahashi T; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri. Electronic address: tsuyoshi.takahashi@wustl.edu.
  • Terada Y; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Meyers BF; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Kozower BD; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Patterson GA; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Nava RG; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Hachem RR; Division of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
  • Witt CA; Division of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
  • Byers DE; Division of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
  • Kulkarni HS; Division of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
  • Guillamet RV; Division of Pulmonology and Critical Care, Washington University, St. Louis, Missouri.
  • Yan Y; Division of Public Health Sciences, Washington University, St. Louis, Missouri.
  • Chang SH; Division of Public Health Sciences, Washington University, St. Louis, Missouri.
  • Kreisel D; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
  • Puri V; Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri.
J Heart Lung Transplant ; 41(12): 1729-1735, 2022 12.
Article en En | MEDLINE | ID: mdl-35970646
BACKGROUND: With advancements in basic science and clinical medicine, lung transplantation (LT) has evolved rapidly over the last three decades. However, it is unclear if significant regional variations exist in long-term outcomes after LT. METHODS: To investigate potential differences, we performed a retrospective, comparative cohort analysis of adult patients undergoing deceased donor single or double LT in North America (NA) or Europe between January 2006 and December 2016. Data up to April 2019 were abstracted from the International Society for Heart and Lung Transplantation (ISHLT) Thoracic Organ Registry. We compared overall survival (OS) between North American and European LT centers in a propensity score matched analysis. RESULTS: In 3,115 well-matched pairs, though 30-day survival was similar between groups (NA 96.2% vs Europe 95.4%, p = 0.116), 5-year survival was significantly higher in European patients (NA 60.1% vs Europe 70.3%, p < 0.001). CONCLUSIONS: This survival difference persisted in a sensitivity analysis excluding Canadian patients. Prior observations suggest that these disparities are at least partly related to better access to care via universal healthcare models prevalent in Europe. Future studies are warranted to confirm our findings and explore other causal mechanisms. It is likely that potential solutions will require concerted efforts from healthcare providers and policymakers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón-Pulmón / Trasplante de Pulmón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón-Pulmón / Trasplante de Pulmón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos