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The relationship between meniscal pathologies, cartilage loss, joint replacement and pain in knee osteoarthritis: a systematic review.
Ghouri, A; Muzumdar, S; Barr, A J; Robinson, E; Murdoch, C; Kingsbury, S R; Conaghan, P G.
Afiliación
  • Ghouri A; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address: a.a.ghouri@leeds.ac.uk.
  • Muzumdar S; The Royal Free Hospital, London, UK. Electronic address: Siddhant.muzumdar@nhs.net.
  • Barr AJ; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address: a.barr@leeds.ac.uk.
  • Robinson E; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address: eleanor.robinson8@nhs.net.
  • Murdoch C; Calderdale and Huddersfield NHS Foundation Trust, UK. Electronic address: calum.murdoch@nhs.net.
  • Kingsbury SR; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address: s.r.kingsbury@leeds.ac.uk.
  • Conaghan PG; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address: p.conaghan@leeds.ac.uk.
Osteoarthritis Cartilage ; 30(10): 1287-1327, 2022 10.
Article en En | MEDLINE | ID: mdl-35963512
OBJECTIVE: We conducted a systematic review in order to understand the relationship between imaging-visualised meniscus pathologies, hyaline cartilage, joint replacement and pain in knee osteoarthritis (OA). DESIGN: A search of the Medline, Excerpta Medica database (EMBASE) and Cochrane library databases was performed for original publications reporting association between imaging-detected meniscal pathology (extrusion or tear/damage) and longitudinal and cross-sectional assessments of hyaline articular cartilage loss [assessed on magnetic resonance imaging (MRI)], incident joint replacement and pain (longitudinal and cross-sectional) in knee OA. Each association was qualitatively characterised by a synthesis of data from each analysis, based upon study design and quality scoring (including risk of bias assessment and adequacy of covariate adjustment using Cochrane recommended methodology). RESULTS: In total 4,878 abstracts were screened and 82 publications were included (comprising 72 longitudinal analyses and 49 cross-sectional). Using high quality, well-adjusted data, meniscal extrusion and meniscal tear/damage were associated with longitudinal progression of cartilage loss, cross-sectional cartilage loss severity and joint replacement, independently of age, sex and body mass index (BMI). Medial and lateral meniscal tears were associated with cartilage loss when they occurred in the body and posterior horns, but not the anterior horns. There was a lack of high quality, well-adjusted meniscal pathology and pain publications and no clear independent association between meniscal extrusion or tear/damage with pain severity, progression in pain or incident frequent knee symptoms. CONCLUSION: Meniscal features have strong associations with cartilage loss and joint replacement in knee OA, but weak associations with knee pain. Systematic review PROSPERO registration number: CRD 42020210910.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Artroplastia de Reemplazo / Osteoartritis de la Rodilla Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Osteoarthritis Cartilage Asunto de la revista: ORTOPEDIA / REUMATOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Artroplastia de Reemplazo / Osteoartritis de la Rodilla Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Osteoarthritis Cartilage Asunto de la revista: ORTOPEDIA / REUMATOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido