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Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis.
Nagasao, J; Fukasawa, H; Yoshioka, K; Fujimura, N; Kobayashi, M; Tsunemi, Y; Nomoto, A; Mitsui, S; Murata, H; Yokoyama, I; Komiya, Y; Arihara, K.
Afiliación
  • Nagasao J; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan. Electronic address: nagasao@vmas.kitasato-u.ac.jp.
  • Fukasawa H; Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Yoshioka K; Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Fujimura N; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Kobayashi M; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Tsunemi Y; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Nomoto A; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Mitsui S; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Murata H; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Yokoyama I; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Komiya Y; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
  • Arihara K; Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Poult Sci ; 101(10): 102045, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35961253
We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL). Eleven hens, approximately 104 weeks old, were randomly assigned to BDL (n = 4) and sham surgery (SHAM; n = 7) groups. In BDL hens, histopathology revealed marked bile duct proliferation and liver fibrosis. The cross-sectional area (CSA) of myofibers from both the pectoralis (PCT) muscles significantly decreased in the BDL group compared with the SHAM group (P < 0.01). In contrast, the CSA of myofibers from the femorotibialis lateralis (FTL) muscle did not decrease in the BDL group. Type I fibers were large, round, and hypertrophic. Elongated type IIA and IIB fibers were also present. For IGF-1 immunostaining, the immunoreaction intensity was higher in the PCT in the BDL group than the SHAM group. Within the BDL group, type I fibers from FTL had a stronger immunoreaction intensity than the type II fibers. For IGF-1R immunostaining, the intensity of the immunoreactions was similar within the PCT in the BDL group compared with the SHAM group. For FTL, type I fibers had stronger reactions to IGF-1R than type II fibers in the BDL group. These results suggest that type I fibers express both IGF-1 and IGF-1R and become hypertrophic in chickens with hepatic fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Pollos Límite: Animals Idioma: En Revista: Poult Sci Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Pollos Límite: Animals Idioma: En Revista: Poult Sci Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido