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Bone mass and biomarkers in young women with anorexia nervosa: a prospective 3-year follow-up study.
Svedlund, Anna; Pettersson, Cecilia; Tubic, Bojan; Ellegård, Lars; Elfvin, Anders; Magnusson, Per; Swolin-Eide, Diana.
Afiliación
  • Svedlund A; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. anna.svedlund@gu.se.
  • Pettersson C; Region Västra Götaland, Sahlgrenska University Hospital, Queen Silvia Children's Hospital, Department of Pediatrics, Gothenburg, Sweden. anna.svedlund@gu.se.
  • Tubic B; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Ellegård L; Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Elfvin A; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Magnusson P; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Swolin-Eide D; Region Västra Götaland, Sahlgrenska University Hospital, Queen Silvia Children's Hospital, Department of Pediatrics, Gothenburg, Sweden.
J Bone Miner Metab ; 40(6): 974-989, 2022 Nov.
Article en En | MEDLINE | ID: mdl-35960382
INTRODUCTION: Anorexia nervosa (AN) increases the risk of impaired bone health, low areal bone mineral density (aBMD), and subsequent fractures. This prospective study investigated the long-term effects of bone and mineral metabolism on bone and biomarkers in 22 women with AN. MATERIALS AND METHODS: Body composition and aBMD were measured by dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography. Total and free 25-hydroxyvitamin D (25OHD), C-terminal collagen cross-links (CTX), osteocalcin, bone-specific alkaline phosphatase (BALP), leptin, sclerostin, and oxidized/non-oxidized parathyroid hormone (PTH) were analyzed before and after 12 weeks of intensive nutrition therapy and again 3 years later. An age-matched comparison group of 17 healthy women was recruited for the 3-year follow-up. RESULTS: Body mass index (BMI) and fat mass increased from baseline to 3 years in women with AN. Sclerostin decreased during nutrition therapy and further over 3 years, indicating reduced bone loss. CTX was elevated at baseline and after 12 weeks but decreased over 3 years. BALP increased during nutrition therapy and stabilized over 3 years. Free 25OHD was stable during treatment but decreased over 3 years. Non-oxidized PTH was stable during treatment but increased over 3 years. Trabecular volumetric BMD in AN patients decreased during the first 12 weeks and over 3 years despite stable BMI and bone biomarkers implying increased BMD. CONCLUSION: Our findings highlight the importance of early detection and organized long-term follow-up of bone health in young women with a history of AN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Densidad Ósea Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Densidad Ósea Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Japón