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Impact of acupuncture and integrative therapies on chemotherapy-induced peripheral neuropathy: A multicentered, randomized controlled trial.
Ben-Arye, Eran; Hausner, David; Samuels, Noah; Gamus, Dorit; Lavie, Ofer; Tadmor, Tamar; Gressel, Orit; Agbarya, Abed; Attias, Samuel; David, Adi; Schiff, Elad.
Afiliación
  • Ben-Arye E; Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
  • Hausner D; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Samuels N; Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
  • Gamus D; Palliative Care Service, Chaim Sheba Medical Center, Ramat Gan, Israel.
  • Lavie O; Center for Integrative Complementary Medicine, Shaarei Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Tadmor T; Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
  • Gressel O; Complementary and Integrative Medicine Service, Sheba Medical Center, Ramat-Gan, Israel.
  • Agbarya A; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Attias S; Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
  • David A; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Schiff E; Unit of Hematology, Bnai Zion Medical Center, Haifa, Israel.
Cancer ; 128(20): 3641-3652, 2022 10.
Article en En | MEDLINE | ID: mdl-35960141
BACKGROUND: To explore the impact of acupuncture with other complementary and integrative medicine (CIM) modalities on chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QoL) in oncology patients. METHODS: In this prospective, pragmatic, and patient-preference study, patients with CIPN were treated with acupuncture and CIM therapies (intervention group) or standard care alone (controls) for 6 weeks. Patients in the intervention arm were randomized to twice-weekly acupuncture-only (group A) or acupuncture with additional manual-movement or mind-body CIM therapies (group B). Severity of CIPN was assessed at baseline and at 6 weeks using the Functional Assessment of Cancer Therapy-Taxane (FACT-Tax) tool. Other QoL-related outcomes were assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC); and the Measure Yourself Concerns and Well-being questionnaire. Von Frey measurements examined perception thresholds. RESULTS: Of 168 participants, 136 underwent the study intervention (group A, 69; group B, 67), with 32 controls. Baseline-to-6-week assessment scores improved significantly in the intervention arm (vs controls) on FACT-Tax (p = .038) and emotional well-being (p = .04) scores; FACT-TAX scores for hand numbness/tingling (p = .007) and discomfort (p < .0001); and EORTC physical functioning (p = .045). Intervention groups A and B showed improved FACT-Tax physical well-being (p < .001), FACT-TAX total score (p < .001), FACT-TAX feet discomfort (p = .003), and EORTC pain (p = .017) scores. CONCLUSIONS: Acupuncture, with or without CIM modalities, can relieve CIPN-related symptoms during oncology treatment. This is most pronounced for hand numbness, tingling, pain, discomfort, and for physical functioning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Acupuntura / Enfermedades del Sistema Nervioso Periférico / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Guideline / Observational_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Cancer Año: 2022 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Acupuntura / Enfermedades del Sistema Nervioso Periférico / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Guideline / Observational_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Cancer Año: 2022 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos